Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

Zainuddin, Norafiza ; Murray, Fiona ; Kanduri, Meena ; Gunnarsson, Rebeqa LU ; Smedby, Karin E. ; Enblad, Gunilla ; Jurlander, Jesper ; Juliusson, Gunnar LU and Rosenquist, Richard (2011) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 35(2). p.272-274
Abstract
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease... (More)
TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
TP53 mutation, 17p-deletion, Prognosis, Chronic lymphocytic leukemia
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
35
issue
2
pages
272 - 274
publisher
Elsevier
external identifiers
  • wos:000286460200024
  • scopus:78751702338
  • pmid:20870288
ISSN
1873-5835
DOI
10.1016/j.leukres.2010.08.023
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)
id
607dac1d-fa58-4df6-a17f-eca7532d14dc (old id 1790700)
date added to LUP
2016-04-01 09:56:48
date last changed
2022-07-21 04:59:36
@article{607dac1d-fa58-4df6-a17f-eca7532d14dc,
  abstract     = {{TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression. (C) 2010 Elsevier Ltd. All rights reserved.}},
  author       = {{Zainuddin, Norafiza and Murray, Fiona and Kanduri, Meena and Gunnarsson, Rebeqa and Smedby, Karin E. and Enblad, Gunilla and Jurlander, Jesper and Juliusson, Gunnar and Rosenquist, Richard}},
  issn         = {{1873-5835}},
  keywords     = {{TP53 mutation; 17p-deletion; Prognosis; Chronic lymphocytic leukemia}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{272--274}},
  publisher    = {{Elsevier}},
  series       = {{Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis}},
  title        = {{TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia}},
  url          = {{https://lup.lub.lu.se/search/files/1414614/1858243.pdf}},
  doi          = {{10.1016/j.leukres.2010.08.023}},
  volume       = {{35}},
  year         = {{2011}},
}