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Muscular exercise can cause highly pathological liver function tests in healthy men.

Pettersson, Jonas; Hindorf, Ulf; Persson, Paula; Bengtsson, Thomas; Malmqvist, Ulf LU ; Werkström, Viktoria LU and Ekelund, Mats (2008) In British Journal of Clinical Pharmacology 65(2). p.253-259
Abstract
What is already known about this subject



• The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals.



• Physical exercise can result in transient elevations of liver function tests.



• There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent.



What this study adds



• Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting.



• Liver function tests are... (More)
What is already known about this subject



• The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals.



• Physical exercise can result in transient elevations of liver function tests.



• There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent.



What this study adds



• Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting.



• Liver function tests are significantly increased for at least 7 days after weightlifting.



• It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies.



Aim



To investigate the effect of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting liver function in healthy men.



Methods



Fifteen healthy men, used to moderate physical activity not including weightlifting, performed an 1 h long weightlifting programme. Blood was sampled for clinical chemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma-glutamyl transferase (γGT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK) and myoglobin] at repeated intervals during 7 days postexercise and at a follow-up examination 10–12 days postexercise.



Results



Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P < 0.01) and remained increased for at least 7 days postexercise. Bilirubin, γGT and ALP remained within the normal range.



Conclusion



The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Clinical Pharmacology
volume
65
issue
2
pages
253 - 259
publisher
John Wiley & Sons
external identifiers
  • wos:000252773800017
  • scopus:38649105472
ISSN
1365-2125
DOI
10.1111/j.1365-2125.2007.03001.x
language
English
LU publication?
yes
id
cd35c777-2589-48d4-999e-b2c9bcabbf04 (old id 608027)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17764474&dopt=Abstract
date added to LUP
2008-08-05 14:19:01
date last changed
2017-11-05 03:47:55
@article{cd35c777-2589-48d4-999e-b2c9bcabbf04,
  abstract     = {What is already known about this subject<br/><br>
<br/><br>
• The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the leading cause of postmarketing warnings and withdrawals.<br/><br>
<br/><br>
• Physical exercise can result in transient elevations of liver function tests.<br/><br>
<br/><br>
• There is no consensus in the literature on which forms of exercise may cause changes in liver function tests and to what extent.<br/><br>
<br/><br>
What this study adds<br/><br>
<br/><br>
• Weightlifting results in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting.<br/><br>
<br/><br>
• Liver function tests are significantly increased for at least 7 days after weightlifting.<br/><br>
<br/><br>
• It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies.<br/><br>
 <br/><br>
Aim<br/><br>
<br/><br>
To investigate the effect of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting liver function in healthy men.<br/><br>
 <br/><br>
Methods<br/><br>
<br/><br>
Fifteen healthy men, used to moderate physical activity not including weightlifting, performed an 1 h long weightlifting programme. Blood was sampled for clinical chemistry parameters [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma-glutamyl transferase (γGT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK) and myoglobin] at repeated intervals during 7 days postexercise and at a follow-up examination 10–12 days postexercise.<br/><br>
 <br/><br>
Results<br/><br>
<br/><br>
Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK and myoglobin) increased significantly after exercise (P &lt; 0.01) and remained increased for at least 7 days postexercise. Bilirubin, γGT and ALP remained within the normal range.<br/><br>
 <br/><br>
Conclusion<br/><br>
<br/><br>
The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies. Intensive muscular exercise, e.g. weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice.},
  author       = {Pettersson, Jonas and Hindorf, Ulf and Persson, Paula and Bengtsson, Thomas and Malmqvist, Ulf and Werkström, Viktoria and Ekelund, Mats},
  issn         = {1365-2125},
  language     = {eng},
  number       = {2},
  pages        = {253--259},
  publisher    = {John Wiley & Sons},
  series       = {British Journal of Clinical Pharmacology},
  title        = {Muscular exercise can cause highly pathological liver function tests in healthy men.},
  url          = {http://dx.doi.org/10.1111/j.1365-2125.2007.03001.x},
  volume       = {65},
  year         = {2008},
}