Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles

Tyagi, Gunjan ; Greenfield, Jake L. ; Jones, Beatrice E. ; Sharratt, William N. ; Khan, Kasim LU ; Seddon, Dale ; Malone, Lorna A. ; Cowieson, Nathan ; Evans, Rachel C. and Fuchter, Matthew J. , et al. (2022) In Journal of the American Chemical Society 2(12). p.2670-2677
Abstract

The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The... (More)

The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arylazopyrazole, CTAB, liposome, micelle, photosurfactant, SANS, SAXS
in
Journal of the American Chemical Society
volume
2
issue
12
pages
2670 - 2677
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:36590257
  • scopus:85141568660
ISSN
0002-7863
DOI
10.1021/jacsau.2c00453
language
English
LU publication?
yes
id
60868688-b870-42de-8b7b-254bffa34892
date added to LUP
2022-12-06 15:07:00
date last changed
2024-04-18 16:02:34
@article{60868688-b870-42de-8b7b-254bffa34892,
  abstract     = {{<p>The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.</p>}},
  author       = {{Tyagi, Gunjan and Greenfield, Jake L. and Jones, Beatrice E. and Sharratt, William N. and Khan, Kasim and Seddon, Dale and Malone, Lorna A. and Cowieson, Nathan and Evans, Rachel C. and Fuchter, Matthew J. and Cabral, João T.}},
  issn         = {{0002-7863}},
  keywords     = {{arylazopyrazole; CTAB; liposome; micelle; photosurfactant; SANS; SAXS}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2670--2677}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of the American Chemical Society}},
  title        = {{Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles}},
  url          = {{http://dx.doi.org/10.1021/jacsau.2c00453}},
  doi          = {{10.1021/jacsau.2c00453}},
  volume       = {{2}},
  year         = {{2022}},
}