Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles
(2022) In Journal of the American Chemical Society 2(12). p.2670-2677- Abstract
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The... (More)
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- arylazopyrazole, CTAB, liposome, micelle, photosurfactant, SANS, SAXS
- in
- Journal of the American Chemical Society
- volume
- 2
- issue
- 12
- pages
- 2670 - 2677
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:36590257
- scopus:85141568660
- ISSN
- 0002-7863
- DOI
- 10.1021/jacsau.2c00453
- language
- English
- LU publication?
- yes
- id
- 60868688-b870-42de-8b7b-254bffa34892
- date added to LUP
- 2022-12-06 15:07:00
- date last changed
- 2024-09-07 04:29:19
@article{60868688-b870-42de-8b7b-254bffa34892, abstract = {{<p>The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal micelles into smaller, spherical micelles with larger shell thickness. Doping PS with CTAB resulted in mixed micelle formation at all stoichiometries and conditions investigated; employing selectively deuterated PS, a monotonic variation in scattering length density and dimensions of the micellar core and shell is observed for all contrasts. The concentration- and irradiance-dependence of the E to Z configurational transition was established in both neat and mixed micelles. A liposome dye release assay establishes the enhanced efficacy of photosurfactants at membrane disruption, with E-PS exhibiting a 4-fold and Z-PS a 10-fold increase in fluorescence signal with respect to pure CTAB. Our findings pave the way for external triggering and modulation of the wide range of CTAB-based biomedical and material applications.</p>}}, author = {{Tyagi, Gunjan and Greenfield, Jake L. and Jones, Beatrice E. and Sharratt, William N. and Khan, Kasim and Seddon, Dale and Malone, Lorna A. and Cowieson, Nathan and Evans, Rachel C. and Fuchter, Matthew J. and Cabral, João T.}}, issn = {{0002-7863}}, keywords = {{arylazopyrazole; CTAB; liposome; micelle; photosurfactant; SANS; SAXS}}, language = {{eng}}, number = {{12}}, pages = {{2670--2677}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of the American Chemical Society}}, title = {{Light Responsiveness and Assembly of Arylazopyrazole-Based Surfactants in Neat and Mixed CTAB Micelles}}, url = {{http://dx.doi.org/10.1021/jacsau.2c00453}}, doi = {{10.1021/jacsau.2c00453}}, volume = {{2}}, year = {{2022}}, }