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Signaling pathways governing stem cell fate.

Blank Savukinas, Ulrika LU ; Karlsson, Göran LU and Karlsson, Stefan LU (2008) In Blood 111(2). p.492-503
Abstract
Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulating fate events, such as self-renewal and differentiation, have remained elusive. Recently, several developmentally conserved signaling pathways have emerged as important control devices of HSC fate, including Notch, Wingless-type (Wnt), Sonic hedgehog (Shh), and Smad pathways. HSCs reside in a complex environment in the bone marrow, providing a niche... (More)
Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulating fate events, such as self-renewal and differentiation, have remained elusive. Recently, several developmentally conserved signaling pathways have emerged as important control devices of HSC fate, including Notch, Wingless-type (Wnt), Sonic hedgehog (Shh), and Smad pathways. HSCs reside in a complex environment in the bone marrow, providing a niche that optimally balances signals that control self-renewal and differentiation. These signaling circuits provide a valuable structure for our understanding of how HSC regulation occurs, concomitantly with providing information of how the bone marrow microenvironment couples and integrates extrinsic with intrinsic HSC fate determinants. It is the focus of this review to highlight some of the most recent developments concerning signaling pathways governing HSC fate. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
111
issue
2
pages
492 - 503
publisher
American Society of Hematology
external identifiers
  • wos:000252458700017
  • scopus:38349121930
ISSN
1528-0020
DOI
10.1182/blood-2007-07-075168
language
English
LU publication?
yes
id
7b74ea62-f42b-48d8-b9aa-1e161f3d2fdf (old id 608773)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17914027&dopt=Abstract
date added to LUP
2008-01-04 11:13:26
date last changed
2017-09-17 08:25:14
@article{7b74ea62-f42b-48d8-b9aa-1e161f3d2fdf,
  abstract     = {Hematopoietic stem cells (HSCs) are historically the most thoroughly characterized type of adult stem cell, and the hematopoietic system has served as a principal model structure of stem-cell biology for several decades. However, paradoxically, although HSCs can be defined by function and even purified to near-homogeneity, the intricate molecular machinery and the signaling mechanisms regulating fate events, such as self-renewal and differentiation, have remained elusive. Recently, several developmentally conserved signaling pathways have emerged as important control devices of HSC fate, including Notch, Wingless-type (Wnt), Sonic hedgehog (Shh), and Smad pathways. HSCs reside in a complex environment in the bone marrow, providing a niche that optimally balances signals that control self-renewal and differentiation. These signaling circuits provide a valuable structure for our understanding of how HSC regulation occurs, concomitantly with providing information of how the bone marrow microenvironment couples and integrates extrinsic with intrinsic HSC fate determinants. It is the focus of this review to highlight some of the most recent developments concerning signaling pathways governing HSC fate.},
  author       = {Blank Savukinas, Ulrika and Karlsson, Göran and Karlsson, Stefan},
  issn         = {1528-0020},
  language     = {eng},
  number       = {2},
  pages        = {492--503},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Signaling pathways governing stem cell fate.},
  url          = {http://dx.doi.org/10.1182/blood-2007-07-075168},
  volume       = {111},
  year         = {2008},
}