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DAK, a new low-incidence antigen in the Rh blood group system

Reid, Marion E ; Storry, Jill LU ; Sausais, Laima ; Tossas, Edith ; Rios, Maria ; Hue-Roye, Kim ; Gloster, Elizabeth S ; Miller, Scott T ; Wolf, Carl and Lomas-Francis, Christine (2003) In Transfusion 43(10). p.1394-1397
Abstract
BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could... (More)
BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054). (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Transfusion
volume
43
issue
10
pages
1394 - 1397
publisher
Wiley-Blackwell
external identifiers
  • pmid:14507270
  • scopus:0142135468
ISSN
1537-2995
DOI
10.1046/j.1537-2995.2003.00517.x
language
English
LU publication?
no
id
60ab5664-8a67-4ced-a965-6bb6a4cc9859 (old id 1126502)
date added to LUP
2016-04-01 16:58:46
date last changed
2022-01-28 23:28:34
@article{60ab5664-8a67-4ced-a965-6bb6a4cc9859,
  abstract     = {{BACKGROUND: Some low-incidence antigens in the Rh blood group system (e.g., VS, Rh32, FPTT) are expressed by more than one Rh complex. We describe a new low-incidence antigen that is present on RBCs with the partial D phenotypes, DIIIa or DOL, on RN RBCs and on one example of STEM+S RBCs. STUDY DESIGN AND METHODS: Standard hemagglutination testing was performed with two sera that agglutinated DIIIa RBCs on our in-house antibody identification panel. DNA-based assays were performed on selected samples. RESULTS: RBCs with the DIIIa (n = 31), DOL (n = 5), or RN (n = 10) phenotype were agglutinated by both sera, as were RBCs from one STEM+S person. Reactivity with RBCs of either DIIIa or DOL phenotypes was stronger than with RN RBCs and could not be separated by adsorption and elution. CONCLUSION: An antibody, anti-DAK, which recognizes a novel low-incidence antigen that is more strongly expressed on DIIIa and DOL RBCs than on RN RBCs is described. The antibody agglutinated RBCs from 4 percent of D+ African American blood donors in New York. The antigen, DAK, has been assigned the ISBT number RH54 (004.054).}},
  author       = {{Reid, Marion E and Storry, Jill and Sausais, Laima and Tossas, Edith and Rios, Maria and Hue-Roye, Kim and Gloster, Elizabeth S and Miller, Scott T and Wolf, Carl and Lomas-Francis, Christine}},
  issn         = {{1537-2995}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1394--1397}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Transfusion}},
  title        = {{DAK, a new low-incidence antigen in the Rh blood group system}},
  url          = {{http://dx.doi.org/10.1046/j.1537-2995.2003.00517.x}},
  doi          = {{10.1046/j.1537-2995.2003.00517.x}},
  volume       = {{43}},
  year         = {{2003}},
}