Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.
(2014) In Scandinavian Journal of Immunology 79(4). p.237-243- Abstract
- The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune... (More)
- The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive. This article is protected by copyright. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4292215
- author
- Källberg, Eva LU ; Ivars, Fredrik LU and Leanderson, Tomas LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Immunology
- volume
- 79
- issue
- 4
- pages
- 237 - 243
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:24383944
- wos:000333237000002
- scopus:84897833283
- pmid:24383944
- ISSN
- 1365-3083
- DOI
- 10.1111/sji.12152
- language
- English
- LU publication?
- yes
- id
- 60b449e3-47a5-45ed-9383-466d2ef12b16 (old id 4292215)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24383944?dopt=Abstract
- date added to LUP
- 2016-04-01 09:49:35
- date last changed
- 2022-01-25 17:01:34
@article{60b449e3-47a5-45ed-9383-466d2ef12b16,
abstract = {{The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive. This article is protected by copyright. All rights reserved.}},
author = {{Källberg, Eva and Ivars, Fredrik and Leanderson, Tomas}},
issn = {{1365-3083}},
language = {{eng}},
number = {{4}},
pages = {{237--243}},
publisher = {{Wiley-Blackwell}},
series = {{Scandinavian Journal of Immunology}},
title = {{Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.}},
url = {{http://dx.doi.org/10.1111/sji.12152}},
doi = {{10.1111/sji.12152}},
volume = {{79}},
year = {{2014}},
}