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Macular function in preterm children at school age

Åkerblom, Hanna; Andreasson, Sten LU and Holmström, Gerd (2016) In Documenta Ophthalmologica 133(3). p.151-157
Abstract

Purpose: Macular development is a complex process that starts by mid-gestation and continues several years after birth. A preterm birth could affect this development, causing increased thickness in the central macula, but the effect of the macular function remains uncertain. The aim of this study was to investigate the macular function measured with multifocal electroretinography (mfERG), in former preterm children and compare with healthy controls. A second aim was to correlate central macular function with central macular thickness measured with optical coherent tomography (OCT), in the preterm group. Methods: Fifteen former preterm children born before 32 weeks of gestation were included in the study. MfERG results from 12 children... (More)

Purpose: Macular development is a complex process that starts by mid-gestation and continues several years after birth. A preterm birth could affect this development, causing increased thickness in the central macula, but the effect of the macular function remains uncertain. The aim of this study was to investigate the macular function measured with multifocal electroretinography (mfERG), in former preterm children and compare with healthy controls. A second aim was to correlate central macular function with central macular thickness measured with optical coherent tomography (OCT), in the preterm group. Methods: Fifteen former preterm children born before 32 weeks of gestation were included in the study. MfERG results from 12 children acted as controls. Visual acuity, refraction in cycloplegia and mfERG were carried out in all children, and optical coherent tomography (OCT) was performed in the preterm children. Main outcomes were P1 amplitudes and implicit times for Rings 1–5 and “sum of groups” of the mfERG, and central macula thickness in area A1 measured with OCT. Results: The P1 amplitudes were reduced in Rings 1–5 and “Sum of groups” in the preterm children compared to controls. There were no significant correlation between P1 amplitude or implicit times in Ring 1 and central macular thickness in the preterm group. Conclusions: Macular function is reduced in former preterm children compared to children born at term. This suggests that the structural changes with a thicker central retina can have an effect on function and may be one, of probably several, explanations for visual dysfunction in preterm children at school age.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Macula, Multifocal electroretinogram (mfERG), Optical coherent tomography (OCT), Preterm children
in
Documenta Ophthalmologica
volume
133
issue
3
pages
151 - 157
publisher
Springer
external identifiers
  • scopus:84994791364
  • wos:000388974900001
ISSN
0012-4486
DOI
10.1007/s10633-016-9564-8
language
English
LU publication?
yes
id
60b4a9c5-3ce2-47cf-a7b8-b8b96cce6e67
date added to LUP
2016-11-28 12:19:28
date last changed
2017-10-22 05:22:39
@article{60b4a9c5-3ce2-47cf-a7b8-b8b96cce6e67,
  abstract     = {<p>Purpose: Macular development is a complex process that starts by mid-gestation and continues several years after birth. A preterm birth could affect this development, causing increased thickness in the central macula, but the effect of the macular function remains uncertain. The aim of this study was to investigate the macular function measured with multifocal electroretinography (mfERG), in former preterm children and compare with healthy controls. A second aim was to correlate central macular function with central macular thickness measured with optical coherent tomography (OCT), in the preterm group. Methods: Fifteen former preterm children born before 32 weeks of gestation were included in the study. MfERG results from 12 children acted as controls. Visual acuity, refraction in cycloplegia and mfERG were carried out in all children, and optical coherent tomography (OCT) was performed in the preterm children. Main outcomes were P1 amplitudes and implicit times for Rings 1–5 and “sum of groups” of the mfERG, and central macula thickness in area A1 measured with OCT. Results: The P1 amplitudes were reduced in Rings 1–5 and “Sum of groups” in the preterm children compared to controls. There were no significant correlation between P1 amplitude or implicit times in Ring 1 and central macular thickness in the preterm group. Conclusions: Macular function is reduced in former preterm children compared to children born at term. This suggests that the structural changes with a thicker central retina can have an effect on function and may be one, of probably several, explanations for visual dysfunction in preterm children at school age.</p>},
  author       = {Åkerblom, Hanna and Andreasson, Sten and Holmström, Gerd},
  issn         = {0012-4486},
  keyword      = {Macula,Multifocal electroretinogram (mfERG),Optical coherent tomography (OCT),Preterm children},
  language     = {eng},
  number       = {3},
  pages        = {151--157},
  publisher    = {Springer},
  series       = {Documenta Ophthalmologica},
  title        = {Macular function in preterm children at school age},
  url          = {http://dx.doi.org/10.1007/s10633-016-9564-8},
  volume       = {133},
  year         = {2016},
}