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Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium. A multicentre study from the Swedish Contact Dermatitis Research Group

Isaksson, Marléne LU ; Hagvall, Lina ; Glas, Bo ; Lagrelius, Maria ; Lidén, Carola ; Matura, Mihaly ; Nyman, Gunnar ; Stenberg, Berndt ; Svedman, Cecilia LU and Bruze, Magnus LU (2021) In Contact Dermatitis 84(3). p.153-158
Abstract

Background: In Sweden, cobalt chloride 0.5% has been included in the baseline series since the mid-1980s. A recent study from Stockholm showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world. Objectives: To study the suitability of patch testing to cobalt 1.0% vs 0.5% and to analyze the co-occurrence of allergy to cobalt, chromium, and nickel. Results: Contact allergy to cobalt was shown in 90 patients (6.6%). Eighty (5.9%) patients tested positive to cobalt 1.0%. Thirty-seven of the 90 patients (41.1%) with cobalt allergy were missed by cobalt 0.5% and 10 (0.7%) were missed by cobalt 1.0% (P <.001). No... (More)

Background: In Sweden, cobalt chloride 0.5% has been included in the baseline series since the mid-1980s. A recent study from Stockholm showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world. Objectives: To study the suitability of patch testing to cobalt 1.0% vs 0.5% and to analyze the co-occurrence of allergy to cobalt, chromium, and nickel. Results: Contact allergy to cobalt was shown in 90 patients (6.6%). Eighty (5.9%) patients tested positive to cobalt 1.0%. Thirty-seven of the 90 patients (41.1%) with cobalt allergy were missed by cobalt 0.5% and 10 (0.7%) were missed by cobalt 1.0% (P <.001). No case of patch test sensitization was reported. Allergy to chromium was seen in 2.6% and allergy to nickel in 13.3%. Solitary allergy to cobalt without nickel allergy was shown in 61.1% of cobalt-positive individuals. Female patients had larger proportions of positive reactions to cobalt (P =.036) and nickel (P <.001) than males. Conclusion: The results speak in favor of replacing cobalt chloride 0.5% with cobalt chloride 1.0% pet. in the Swedish baseline series, which will be done 2021.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, chromium allergy, cobalt allergy, contact sensitization, delayed hypersensitivity, nickel allergy, patch testing
in
Contact Dermatitis
volume
84
issue
3
pages
153 - 158
publisher
Wiley-Blackwell
external identifiers
  • scopus:85092911713
  • pmid:32996589
ISSN
0105-1873
DOI
10.1111/cod.13710
language
English
LU publication?
yes
id
60b70209-8725-4a18-a396-d2c63655806e
date added to LUP
2020-11-12 09:36:16
date last changed
2024-06-12 23:44:02
@article{60b70209-8725-4a18-a396-d2c63655806e,
  abstract     = {{<p>Background: In Sweden, cobalt chloride 0.5% has been included in the baseline series since the mid-1980s. A recent study from Stockholm showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world. Objectives: To study the suitability of patch testing to cobalt 1.0% vs 0.5% and to analyze the co-occurrence of allergy to cobalt, chromium, and nickel. Results: Contact allergy to cobalt was shown in 90 patients (6.6%). Eighty (5.9%) patients tested positive to cobalt 1.0%. Thirty-seven of the 90 patients (41.1%) with cobalt allergy were missed by cobalt 0.5% and 10 (0.7%) were missed by cobalt 1.0% (P &lt;.001). No case of patch test sensitization was reported. Allergy to chromium was seen in 2.6% and allergy to nickel in 13.3%. Solitary allergy to cobalt without nickel allergy was shown in 61.1% of cobalt-positive individuals. Female patients had larger proportions of positive reactions to cobalt (P =.036) and nickel (P &lt;.001) than males. Conclusion: The results speak in favor of replacing cobalt chloride 0.5% with cobalt chloride 1.0% pet. in the Swedish baseline series, which will be done 2021.</p>}},
  author       = {{Isaksson, Marléne and Hagvall, Lina and Glas, Bo and Lagrelius, Maria and Lidén, Carola and Matura, Mihaly and Nyman, Gunnar and Stenberg, Berndt and Svedman, Cecilia and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis; chromium allergy; cobalt allergy; contact sensitization; delayed hypersensitivity; nickel allergy; patch testing}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{153--158}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Suitable test concentration of cobalt and concomitant reactivity to nickel and chromium. A multicentre study from the Swedish Contact Dermatitis Research Group}},
  url          = {{http://dx.doi.org/10.1111/cod.13710}},
  doi          = {{10.1111/cod.13710}},
  volume       = {{84}},
  year         = {{2021}},
}