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Transcription factor-mediated reprogramming to antigen-presenting cells

Ascic, Ervin LU orcid and Pereira, Carlos-Filipe LU orcid (2025) In Current Opinion in Genetics & Development 90.
Abstract

Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explored to generate APC subsets, including enrichment from peripheral blood and differentiation from pluripotent or multipotent cells. During development, the generation of APC subsets is instructed by transcription factors (TFs). Direct cell reprogramming, also known as transdifferentiation, offers an approach to harness combinations of TFs to generate APCs from unrelated somatic cells, including cancer cells. In this review, we summarize the transcriptional specification of DC subsets, highlight... (More)

Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explored to generate APC subsets, including enrichment from peripheral blood and differentiation from pluripotent or multipotent cells. During development, the generation of APC subsets is instructed by transcription factors (TFs). Direct cell reprogramming, also known as transdifferentiation, offers an approach to harness combinations of TFs to generate APCs from unrelated somatic cells, including cancer cells. In this review, we summarize the transcriptional specification of DC subsets, highlight transcriptional networks for their generation, and discuss future applications of DC reprogramming in cancer immunotherapy.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Genetics & Development
volume
90
article number
102300
publisher
Elsevier
external identifiers
  • pmid:39721321
  • scopus:85212842269
ISSN
1879-0380
DOI
10.1016/j.gde.2024.102300
language
English
LU publication?
yes
additional info
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
id
60ba26bc-1acd-4f0a-b012-197171ac6f2b
date added to LUP
2024-12-28 20:13:57
date last changed
2025-01-12 05:10:40
@article{60ba26bc-1acd-4f0a-b012-197171ac6f2b,
  abstract     = {{<p>Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explored to generate APC subsets, including enrichment from peripheral blood and differentiation from pluripotent or multipotent cells. During development, the generation of APC subsets is instructed by transcription factors (TFs). Direct cell reprogramming, also known as transdifferentiation, offers an approach to harness combinations of TFs to generate APCs from unrelated somatic cells, including cancer cells. In this review, we summarize the transcriptional specification of DC subsets, highlight transcriptional networks for their generation, and discuss future applications of DC reprogramming in cancer immunotherapy.</p>}},
  author       = {{Ascic, Ervin and Pereira, Carlos-Filipe}},
  issn         = {{1879-0380}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Genetics & Development}},
  title        = {{Transcription factor-mediated reprogramming to antigen-presenting cells}},
  url          = {{http://dx.doi.org/10.1016/j.gde.2024.102300}},
  doi          = {{10.1016/j.gde.2024.102300}},
  volume       = {{90}},
  year         = {{2025}},
}