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Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy

Botha-le Roux, Shani ; Elvstam, Olof LU orcid ; De Boever, Patrick ; Goswami, Nandu ; Magnusson, Martin LU orcid ; Nilsson, Peter M. LU ; Strijdom, Hans ; Björkman, Per LU orcid and Fourie, Carla M. T. (2022) In Journal of Clinical Medicine 11(10).
Abstract
Chronic inflammation is an HIV infection feature, contributing to elevated risk of cardiovascular disease among people with HIV, which can be induced by viral replication. A proportion of antiretroviral therapy (ART) recipients fail to achieve viral suppression, despite not meeting criteria for treatment failure, so-called low-level viremia (LLV). We investigated the relationship between LLV and an array of cardiovascular measures and biomarkers. South Africans with LLV (viral load = 50–999 copies/mL) and virological suppression (viral load <50 copies/mL) were selected from the EndoAfrica study (all receiving efavirenz-based ART) for cross-sectional comparison of vascular structure and function measures, as well as 21 plasma biomarkers... (More)
Chronic inflammation is an HIV infection feature, contributing to elevated risk of cardiovascular disease among people with HIV, which can be induced by viral replication. A proportion of antiretroviral therapy (ART) recipients fail to achieve viral suppression, despite not meeting criteria for treatment failure, so-called low-level viremia (LLV). We investigated the relationship between LLV and an array of cardiovascular measures and biomarkers. South Africans with LLV (viral load = 50–999 copies/mL) and virological suppression (viral load <50 copies/mL) were selected from the EndoAfrica study (all receiving efavirenz-based ART) for cross-sectional comparison of vascular structure and function measures, as well as 21 plasma biomarkers related to cardiovascular risk and inflammation. Associations were investigated with univariate, multivariate, and binomial logistic regression analyses (having outcome measures above (cases) or below (controls) the 75th percentile). Among 208 participants, 95 (46%) had LLV, and 113 (54%) had viral suppression. The median age was 44 years, 73% were women, and the median ART duration was 4.5 years. Cardiovascular measures and biomarker levels were similar between these two categories. Cardiovascular function and structure measures were not associated with viremia status and having LLV did not increase the odds of having outcome measures above the 75th percentile. In this study among South African ART recipients, LLV did not associate with cardiovascular risk. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Medicine
volume
11
issue
10
article number
2812
publisher
MDPI AG
external identifiers
  • scopus:85130048267
  • pmid:35628937
ISSN
2077-0383
DOI
10.3390/jcm11102812
project
Low-level viremia in people living with HIV receiving antiretroviral treatment
language
English
LU publication?
yes
id
60cec5c1-b01c-4c59-b15d-0fb74f0d76a2
date added to LUP
2022-05-19 07:20:27
date last changed
2023-12-05 18:17:00
@article{60cec5c1-b01c-4c59-b15d-0fb74f0d76a2,
  abstract     = {{Chronic inflammation is an HIV infection feature, contributing to elevated risk of cardiovascular disease among people with HIV, which can be induced by viral replication. A proportion of antiretroviral therapy (ART) recipients fail to achieve viral suppression, despite not meeting criteria for treatment failure, so-called low-level viremia (LLV). We investigated the relationship between LLV and an array of cardiovascular measures and biomarkers. South Africans with LLV (viral load = 50–999 copies/mL) and virological suppression (viral load &lt;50 copies/mL) were selected from the EndoAfrica study (all receiving efavirenz-based ART) for cross-sectional comparison of vascular structure and function measures, as well as 21 plasma biomarkers related to cardiovascular risk and inflammation. Associations were investigated with univariate, multivariate, and binomial logistic regression analyses (having outcome measures above (cases) or below (controls) the 75th percentile). Among 208 participants, 95 (46%) had LLV, and 113 (54%) had viral suppression. The median age was 44 years, 73% were women, and the median ART duration was 4.5 years. Cardiovascular measures and biomarker levels were similar between these two categories. Cardiovascular function and structure measures were not associated with viremia status and having LLV did not increase the odds of having outcome measures above the 75th percentile. In this study among South African ART recipients, LLV did not associate with cardiovascular risk.}},
  author       = {{Botha-le Roux, Shani and Elvstam, Olof and De Boever, Patrick and Goswami, Nandu and Magnusson, Martin and Nilsson, Peter M. and Strijdom, Hans and Björkman, Per and Fourie, Carla M. T.}},
  issn         = {{2077-0383}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Cardiovascular Profile of South African Adults with Low-Level Viremia during Antiretroviral Therapy}},
  url          = {{http://dx.doi.org/10.3390/jcm11102812}},
  doi          = {{10.3390/jcm11102812}},
  volume       = {{11}},
  year         = {{2022}},
}