Stressin’ and slicin’ : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth
(2021) In EMBO Journal 40(2).- Abstract
Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/60cf836c-bc50-4921-90fb-3d9b0ad870e4
- author
- Guzzi, Nicola LU and Bellodi, Cristian LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- EMBO Journal
- volume
- 40
- issue
- 2
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85097889755
- pmid:33346912
- ISSN
- 0261-4189
- DOI
- 10.15252/embj.2020107097
- language
- English
- LU publication?
- yes
- id
- 60cf836c-bc50-4921-90fb-3d9b0ad870e4
- date added to LUP
- 2021-01-11 07:41:26
- date last changed
- 2024-06-28 08:16:24
@misc{60cf836c-bc50-4921-90fb-3d9b0ad870e4, abstract = {{<p>Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNA<sub>GUA</sub> fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.</p>}}, author = {{Guzzi, Nicola and Bellodi, Cristian}}, issn = {{0261-4189}}, language = {{eng}}, number = {{2}}, publisher = {{Oxford University Press}}, series = {{EMBO Journal}}, title = {{Stressin’ and slicin’ : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth}}, url = {{http://dx.doi.org/10.15252/embj.2020107097}}, doi = {{10.15252/embj.2020107097}}, volume = {{40}}, year = {{2021}}, }