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Stressin’ and slicin’ : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth

Guzzi, Nicola LU and Bellodi, Cristian LU (2021) In EMBO Journal 40(2).
Abstract

Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
EMBO Journal
volume
40
issue
2
publisher
Oxford University Press
external identifiers
  • scopus:85097889755
  • pmid:33346912
ISSN
0261-4189
DOI
10.15252/embj.2020107097
language
English
LU publication?
yes
id
60cf836c-bc50-4921-90fb-3d9b0ad870e4
date added to LUP
2021-01-11 07:41:26
date last changed
2025-10-14 12:35:22
@misc{60cf836c-bc50-4921-90fb-3d9b0ad870e4,
  abstract     = {{<p>Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNA<sub>GUA</sub> fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.</p>}},
  author       = {{Guzzi, Nicola and Bellodi, Cristian}},
  issn         = {{0261-4189}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Oxford University Press}},
  series       = {{EMBO Journal}},
  title        = {{Stressin’ and slicin’ : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth}},
  url          = {{http://dx.doi.org/10.15252/embj.2020107097}},
  doi          = {{10.15252/embj.2020107097}},
  volume       = {{40}},
  year         = {{2021}},
}