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Is salivary gland ultrasonography a useful tool in Sjögren's syndrome? A systematic review

Jousse-Joulin, Sandrine; Milic, Vera; Jonsson, Malin V. LU ; Plagou, Athena; Theander, Elke LU ; Luciano, Nicoletta; Rachele, Pascale; Baldini, Chiara; Bootsma, Hendrika and Vissink, Arjan, et al. (2016) In Rheumatology1999-01-01+01:00 55(5). p.789-800
Abstract

Objective. Ultrasonography (US) is a sensitive tool in the diagnosis of major salivary gland abnormalities in primary Sjögren's syndrome (pSS). The aim of this systematic review was to assess the metric properties of this technique. Methods. PUBMED and EMBASE databases were searched. All publications between January 1988 and January 2013 were considered. Data were extracted from the articles meeting the inclusion criteria according to US definition of salivary gland scoring system and metric properties studied. The type and number of glands tested, study design and metric properties according to OMERACT filter (truth, discrimination, feasibility) were assessed. Results. Of 167 publications identified initially with PUBMED and EMBASE, 31... (More)

Objective. Ultrasonography (US) is a sensitive tool in the diagnosis of major salivary gland abnormalities in primary Sjögren's syndrome (pSS). The aim of this systematic review was to assess the metric properties of this technique. Methods. PUBMED and EMBASE databases were searched. All publications between January 1988 and January 2013 were considered. Data were extracted from the articles meeting the inclusion criteria according to US definition of salivary gland scoring system and metric properties studied. The type and number of glands tested, study design and metric properties according to OMERACT filter (truth, discrimination, feasibility) were assessed. Results. Of 167 publications identified initially with PUBMED and EMBASE, 31 met the inclusion criteria. The number of pSS patients varied among the studies from 16 to 140. The diagnosis of pSS was in line in most of the cases with the American-European Consensus Group (AECG) classification criteria for Sjögren's syndrome. The US examination was performed in suspected pSS only in studies in which the sensitivity ranged from 45.8 to 91.6% and specificity from 73 to 98.1%. There was heterogeneity in regard to the definition of US in B-mode and few studies used US in colour Doppler. Few studies reported reliability of US and sensitivity to change in pSS. Conclusion. US is a valuable tool for detecting salivary gland abnormalities in pSS. Its reliability has been poorly investigated and there is considerable variation in the definition of US abnormalities. Further studies are required to validate and standardize the US definition of salivary gland in pSS.

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publication status
published
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keywords
Primary sjögren's syndrome, Reliability, Reproducibility, Salivary gland, Ultrasonography, Validity
in
Rheumatology1999-01-01+01:00
volume
55
issue
5
pages
12 pages
publisher
Oxford University Press
external identifiers
  • scopus:84965056789
  • wos:000376107800005
ISSN
1462-0324
DOI
10.1093/rheumatology/kev385
language
English
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yes
id
60eaf413-64d0-4fc3-a43b-202b28a24b23
date added to LUP
2016-06-14 14:11:28
date last changed
2019-06-19 03:05:22
@article{60eaf413-64d0-4fc3-a43b-202b28a24b23,
  abstract     = {<p>Objective. Ultrasonography (US) is a sensitive tool in the diagnosis of major salivary gland abnormalities in primary Sjögren's syndrome (pSS). The aim of this systematic review was to assess the metric properties of this technique. Methods. PUBMED and EMBASE databases were searched. All publications between January 1988 and January 2013 were considered. Data were extracted from the articles meeting the inclusion criteria according to US definition of salivary gland scoring system and metric properties studied. The type and number of glands tested, study design and metric properties according to OMERACT filter (truth, discrimination, feasibility) were assessed. Results. Of 167 publications identified initially with PUBMED and EMBASE, 31 met the inclusion criteria. The number of pSS patients varied among the studies from 16 to 140. The diagnosis of pSS was in line in most of the cases with the American-European Consensus Group (AECG) classification criteria for Sjögren's syndrome. The US examination was performed in suspected pSS only in studies in which the sensitivity ranged from 45.8 to 91.6% and specificity from 73 to 98.1%. There was heterogeneity in regard to the definition of US in B-mode and few studies used US in colour Doppler. Few studies reported reliability of US and sensitivity to change in pSS. Conclusion. US is a valuable tool for detecting salivary gland abnormalities in pSS. Its reliability has been poorly investigated and there is considerable variation in the definition of US abnormalities. Further studies are required to validate and standardize the US definition of salivary gland in pSS.</p>},
  author       = {Jousse-Joulin, Sandrine and Milic, Vera and Jonsson, Malin V. and Plagou, Athena and Theander, Elke and Luciano, Nicoletta and Rachele, Pascale and Baldini, Chiara and Bootsma, Hendrika and Vissink, Arjan and Hocevar, Alojzija and De Vita, Salvatore and Tzioufas, Athanasios G. and Alavi, Zarin and Bowman, Simon J. and Devauchelle-Pensec, Valerie and Brown, Jackie and Carotti, Marina and Carr, Andrew and Macleod, Iain and Rout, Peter Graham John and Salvim, Sara and Stel, A. and Bears, Alan and Bombardieri, Stéphano and Ciapetti, Alessandro and Mandl, Thomas and Ng, Wan Fai and Quartuccio, Luca and Vissink, A. and Salaffi, Fausto and Tomsic, Matija and Tzioufas, Athanasios},
  issn         = {1462-0324},
  keyword      = {Primary sjögren's syndrome,Reliability,Reproducibility,Salivary gland,Ultrasonography,Validity},
  language     = {eng},
  month        = {05},
  number       = {5},
  pages        = {789--800},
  publisher    = {Oxford University Press},
  series       = {Rheumatology1999-01-01+01:00},
  title        = {Is salivary gland ultrasonography a useful tool in Sjögren's syndrome? A systematic review},
  url          = {http://dx.doi.org/10.1093/rheumatology/kev385},
  volume       = {55},
  year         = {2016},
}