Cardiovascular risk factors in attention-deficit/hyperactivity disorder : A family design study of Swedish conscripts
(2022) In International Journal of Methods in Psychiatric Research 31(4).- Abstract
Objective: (1) investigate the associations of attention-deficit/hyperactivity disorder (ADHD) with systolic and diastolic blood pressure, resting heart rate, pulse pressure (PP), physical fitness, and BMI; (2) explore whether cardiovascular risk factors and ADHD share genetic and environmental influences; (3) assess if pharmacological treatment for ADHD influences these associations. Methods: We identified 395,978 individuals born between 1973 and 1991 who had military conscription examinations at a mean age of 18.3 years (SD = 0.57) and their full-siblings within the same cohort (N = 208,060) by linking population-based registers in Sweden. Results: Significantly increased risk of ADHD was observed in individuals with low systolic... (More)
Objective: (1) investigate the associations of attention-deficit/hyperactivity disorder (ADHD) with systolic and diastolic blood pressure, resting heart rate, pulse pressure (PP), physical fitness, and BMI; (2) explore whether cardiovascular risk factors and ADHD share genetic and environmental influences; (3) assess if pharmacological treatment for ADHD influences these associations. Methods: We identified 395,978 individuals born between 1973 and 1991 who had military conscription examinations at a mean age of 18.3 years (SD = 0.57) and their full-siblings within the same cohort (N = 208,060) by linking population-based registers in Sweden. Results: Significantly increased risk of ADHD was observed in individuals with low systolic blood pressure (SBP) and PP, low physical fitness, and in those who had overweight or obesity after adjustments (adjusted Odds Ratio [OR] ranging from 1.10 to 1.45). Full siblings of individuals with low SBP, low physical fitness, and obesity were more likely to receive an ADHD diagnosis compared to full siblings without those risk factors (OR ranging from 1.17 to 1.31). Additionally, analyses showed robust associations between ADHD and low SBP, low physical fitness, and obesity, even in ADHD medication-naïve individuals. Conclusions: Individuals with several cardiovascular risk factors are more often diagnosed with ADHD, regardless of psychiatric comorbidity. These association are not explained by ADHD pharmacotherapy, rather, they are in part due to shared familial risk factors.
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- author
- Garcia-Argibay, Miguel ; Du Rietz, Ebba ; Hartman, Catharina A. ; Lichtenstein, Paul ; Chang, Zheng ; Fava, Cristiano LU ; Cortese, Samuele and Larsson, Henrik
- organization
- publishing date
- 2022-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- attention deficit hyperactivity disorder, blood pressure, cardiovascular risk factors, physical fitness, resting heart rate
- in
- International Journal of Methods in Psychiatric Research
- volume
- 31
- issue
- 4
- article number
- e1930
- publisher
- Wiley
- external identifiers
-
- scopus:85132948038
- pmid:35765813
- ISSN
- 1049-8931
- DOI
- 10.1002/mpr.1930
- language
- English
- LU publication?
- yes
- id
- 60faa0b7-e564-4bf4-885d-6a508ef84aa6
- date added to LUP
- 2022-10-04 14:18:08
- date last changed
- 2024-06-14 18:56:24
@article{60faa0b7-e564-4bf4-885d-6a508ef84aa6,
abstract = {{<p>Objective: (1) investigate the associations of attention-deficit/hyperactivity disorder (ADHD) with systolic and diastolic blood pressure, resting heart rate, pulse pressure (PP), physical fitness, and BMI; (2) explore whether cardiovascular risk factors and ADHD share genetic and environmental influences; (3) assess if pharmacological treatment for ADHD influences these associations. Methods: We identified 395,978 individuals born between 1973 and 1991 who had military conscription examinations at a mean age of 18.3 years (SD = 0.57) and their full-siblings within the same cohort (N = 208,060) by linking population-based registers in Sweden. Results: Significantly increased risk of ADHD was observed in individuals with low systolic blood pressure (SBP) and PP, low physical fitness, and in those who had overweight or obesity after adjustments (adjusted Odds Ratio [OR] ranging from 1.10 to 1.45). Full siblings of individuals with low SBP, low physical fitness, and obesity were more likely to receive an ADHD diagnosis compared to full siblings without those risk factors (OR ranging from 1.17 to 1.31). Additionally, analyses showed robust associations between ADHD and low SBP, low physical fitness, and obesity, even in ADHD medication-naïve individuals. Conclusions: Individuals with several cardiovascular risk factors are more often diagnosed with ADHD, regardless of psychiatric comorbidity. These association are not explained by ADHD pharmacotherapy, rather, they are in part due to shared familial risk factors.</p>}},
author = {{Garcia-Argibay, Miguel and Du Rietz, Ebba and Hartman, Catharina A. and Lichtenstein, Paul and Chang, Zheng and Fava, Cristiano and Cortese, Samuele and Larsson, Henrik}},
issn = {{1049-8931}},
keywords = {{attention deficit hyperactivity disorder; blood pressure; cardiovascular risk factors; physical fitness; resting heart rate}},
language = {{eng}},
number = {{4}},
publisher = {{Wiley}},
series = {{International Journal of Methods in Psychiatric Research}},
title = {{Cardiovascular risk factors in attention-deficit/hyperactivity disorder : A family design study of Swedish conscripts}},
url = {{http://dx.doi.org/10.1002/mpr.1930}},
doi = {{10.1002/mpr.1930}},
volume = {{31}},
year = {{2022}},
}