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Low noise polymeric nanomechanical biosensor

Calleja, Montserrat ; Tamayo, Javier ; Tenje, Maria LU and Boisen, Anja (2006) In Applied Physics Letters 88(11).
Abstract
A sensor device based on a single polymer cantilever and optical readout has been developed for detection of molecular recognition reactions without the need of a reference cantilever for subtraction of unspecific signals. Microcantilevers have been fabricated in the photoresist SU-8 with one surface passivated with a thin fluorocarbon layer. The SU-8 surface is sensitized with biological receptors by applying silanization methods, whereas the fluorocarbon surface remains inert to these processes. The thermal and mechanical properties of the chosen materials allow overcoming the main limitations of gold-coated silicon cantilevers: the temperature, pH, and ionic strength cross sensitivities. This is demonstrated by comparing the response of... (More)
A sensor device based on a single polymer cantilever and optical readout has been developed for detection of molecular recognition reactions without the need of a reference cantilever for subtraction of unspecific signals. Microcantilevers have been fabricated in the photoresist SU-8 with one surface passivated with a thin fluorocarbon layer. The SU-8 surface is sensitized with biological receptors by applying silanization methods, whereas the fluorocarbon surface remains inert to these processes. The thermal and mechanical properties of the chosen materials allow overcoming the main limitations of gold-coated silicon cantilevers: the temperature, pH, and ionic strength cross sensitivities. This is demonstrated by comparing the response of SU-8 cantilevers and that of gold-coated silicon nitride cantilevers to variations in temperature and pH. The sensitivity of the developed polymeric nanomechanical sensor is demonstrated by real-time detection of the human growth hormone with sensitivity in differential surface stress of about 1 mN/m. (Less)
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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Physics Letters
volume
88
issue
11
article number
113901
publisher
American Institute of Physics (AIP)
external identifiers
  • scopus:33645144939
ISSN
0003-6951
DOI
10.1063/1.2187437
language
English
LU publication?
no
id
61044328-715e-4372-86f0-52042c33c23b (old id 3131724)
date added to LUP
2016-04-01 12:12:01
date last changed
2022-02-26 03:13:48
@article{61044328-715e-4372-86f0-52042c33c23b,
  abstract     = {{A sensor device based on a single polymer cantilever and optical readout has been developed for detection of molecular recognition reactions without the need of a reference cantilever for subtraction of unspecific signals. Microcantilevers have been fabricated in the photoresist SU-8 with one surface passivated with a thin fluorocarbon layer. The SU-8 surface is sensitized with biological receptors by applying silanization methods, whereas the fluorocarbon surface remains inert to these processes. The thermal and mechanical properties of the chosen materials allow overcoming the main limitations of gold-coated silicon cantilevers: the temperature, pH, and ionic strength cross sensitivities. This is demonstrated by comparing the response of SU-8 cantilevers and that of gold-coated silicon nitride cantilevers to variations in temperature and pH. The sensitivity of the developed polymeric nanomechanical sensor is demonstrated by real-time detection of the human growth hormone with sensitivity in differential surface stress of about 1 mN/m.}},
  author       = {{Calleja, Montserrat and Tamayo, Javier and Tenje, Maria and Boisen, Anja}},
  issn         = {{0003-6951}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{Applied Physics Letters}},
  title        = {{Low noise polymeric nanomechanical biosensor}},
  url          = {{http://dx.doi.org/10.1063/1.2187437}},
  doi          = {{10.1063/1.2187437}},
  volume       = {{88}},
  year         = {{2006}},
}