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Prevalence of sustained remission in rheumatoid arthritis: impact of criteria sets and disease duration, a Nationwide Study in Sweden

Einarsson, Jon Thorkell LU ; Willim, Minna LU ; Ernestam, Sofia; Saxne, Tore LU ; Geborek, Pierre LU and C Kapetanovic, Meliha LU (2019) In Rheumatology (Oxford, England) 58(2). p.227-236
Abstract
Objectives
The aims of this national study in Sweden of patients with RA were to: examine the prevalence of sustained remission (SR), that is, remission lasting for at least 6 months; compare the prevalence of SR in patients with early RA and established RA; study the timing of onset of and time spent in SR; and study possible predictors of SR.
Methods
Adult patients with RA included in the Swedish Rheumatology Quality registry were studied. The registry was searched for patients fulfilling remission criteria: DAS28-ESR, Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI) and ACR/EULAR remission for at least 6 months. Early RA was defined as symptom duration ⩽6 months at inclusion in the Swedish... (More)
Objectives
The aims of this national study in Sweden of patients with RA were to: examine the prevalence of sustained remission (SR), that is, remission lasting for at least 6 months; compare the prevalence of SR in patients with early RA and established RA; study the timing of onset of and time spent in SR; and study possible predictors of SR.
Methods
Adult patients with RA included in the Swedish Rheumatology Quality registry were studied. The registry was searched for patients fulfilling remission criteria: DAS28-ESR, Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI) and ACR/EULAR remission for at least 6 months. Early RA was defined as symptom duration ⩽6 months at inclusion in the Swedish Rheumatology Quality.
Results
Of 29 084 patients, 12 193 (41.9%) reached DAS28 SR at some time point during follow-up compared with 6445 (22.2%), 6199 (21.3%) and 5087 (17.5%) for CDAI, SDAI and ACR/EULAR SR, respectively. SR was more common in early RA (P < 0.001). The median time from symptom onset to SR was 1.9, 2.4, 2.4 and 2.5 years according to DAS28, CDAI, SDAI and ACR/EULAR criteria, respectively. Lower age, male sex and milder disease characteristics were associated with SR.
Conclusion
The majority of patients in this nationwide study never reached SR. Patients with early RA are more likely to reach SR than patients with established RA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology (Oxford, England)
volume
58
issue
2
pages
9 pages
publisher
Oxford University Press
external identifiers
  • scopus:85050311125
ISSN
1462-0332
DOI
10.1093/rheumatology/key054
language
Swedish
LU publication?
yes
id
6124d210-693f-4f89-ad36-ec04ce2a3cf3
date added to LUP
2019-03-07 12:29:36
date last changed
2019-08-14 04:33:20
@article{6124d210-693f-4f89-ad36-ec04ce2a3cf3,
  abstract     = {Objectives<br>
The aims of this national study in Sweden of patients with RA were to: examine the prevalence of sustained remission (SR), that is, remission lasting for at least 6 months; compare the prevalence of SR in patients with early RA and established RA; study the timing of onset of and time spent in SR; and study possible predictors of SR.<br>
Methods<br>
Adult patients with RA included in the Swedish Rheumatology Quality registry were studied. The registry was searched for patients fulfilling remission criteria: DAS28-ESR, Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI) and ACR/EULAR remission for at least 6 months. Early RA was defined as symptom duration ⩽6 months at inclusion in the Swedish Rheumatology Quality.<br>
Results<br>
Of 29 084 patients, 12 193 (41.9%) reached DAS28 SR at some time point during follow-up compared with 6445 (22.2%), 6199 (21.3%) and 5087 (17.5%) for CDAI, SDAI and ACR/EULAR SR, respectively. SR was more common in early RA (P &lt; 0.001). The median time from symptom onset to SR was 1.9, 2.4, 2.4 and 2.5 years according to DAS28, CDAI, SDAI and ACR/EULAR criteria, respectively. Lower age, male sex and milder disease characteristics were associated with SR.<br>
Conclusion<br>
The majority of patients in this nationwide study never reached SR. Patients with early RA are more likely to reach SR than patients with established RA.},
  author       = {Einarsson, Jon Thorkell and Willim, Minna and Ernestam, Sofia and Saxne, Tore and Geborek, Pierre and C Kapetanovic, Meliha},
  issn         = {1462-0332},
  language     = {swe},
  month        = {02},
  number       = {2},
  pages        = {227--236},
  publisher    = {Oxford University Press},
  series       = {Rheumatology (Oxford, England)},
  title        = {Prevalence of sustained remission in rheumatoid arthritis: impact of criteria sets and disease duration, a Nationwide Study in Sweden},
  url          = {http://dx.doi.org/10.1093/rheumatology/key054},
  volume       = {58},
  year         = {2019},
}