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Using NT-proBNP to detect chronic heart failure in elderly patients with chronic obstructive pulmonary disease

Kaszuba, Elzbieta LU ; Wagner, Bartlomiej; Odeberg, Håkan LU and Halling, Anders LU (2013) In ISRN Family Medicine 2013. p.1-5
Abstract
Objective. To detect chronic heart failure in elderly patients with a registered diagnosis of chronic obstructive pulmonary disease (COPD) treated in Swedish primary health care using natriuretic peptide NT-proBNP. Design. A cross-sectional study. Setting. Two primary health care centres in southeastern Sweden each with about 9000 listed patients. Subjects. Patients aged 65 years and older with a registered diagnosis of COPD. Main Outcome Measures. Percentage of patients with elevated NT-proBNP, percentage of patients with abnormal left ventricular function assessed by echocardiography, and association between elevated NT-proBNP and symptoms, signs, and electrocardiography. Results. Using NT-proBNP threshold of 1200 pg/mL, we could detect... (More)
Objective. To detect chronic heart failure in elderly patients with a registered diagnosis of chronic obstructive pulmonary disease (COPD) treated in Swedish primary health care using natriuretic peptide NT-proBNP. Design. A cross-sectional study. Setting. Two primary health care centres in southeastern Sweden each with about 9000 listed patients. Subjects. Patients aged 65 years and older with a registered diagnosis of COPD. Main Outcome Measures. Percentage of patients with elevated NT-proBNP, percentage of patients with abnormal left ventricular function assessed by echocardiography, and association between elevated NT-proBNP and symptoms, signs, and electrocardiography. Results. Using NT-proBNP threshold of 1200 pg/mL, we could detect and confirm chronic heart failure in 5.6% of the study population with concurrent COPD. An elevated level of NT-proBNP was only associated with nocturia and abnormal electrocardiography. Conclusions. We found considerably fewer cases of heart failure in patients with COPD than could be expected from the results of previous studies. Our study shows the need for developing improved strategies to enhance the validity of a suspected heart failure diagnosis in patients with COPD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic obstructive pulmonary disease (COPD), Heart failure, Diagnose, NT-proBNP, echocardiography
in
ISRN Family Medicine
volume
2013
pages
5 pages
DOI
10.5402/2013/273864
language
English
LU publication?
yes
id
6126e4e3-4b87-48c4-8f49-afe703ad2d4c
date added to LUP
2018-01-29 20:25:06
date last changed
2018-05-29 11:04:15
@article{6126e4e3-4b87-48c4-8f49-afe703ad2d4c,
  abstract     = {Objective. To detect chronic heart failure in elderly patients with a registered diagnosis of chronic obstructive pulmonary disease (COPD) treated in Swedish primary health care using natriuretic peptide NT-proBNP. Design. A cross-sectional study. Setting. Two primary health care centres in southeastern Sweden each with about 9000 listed patients. Subjects. Patients aged 65 years and older with a registered diagnosis of COPD. Main Outcome Measures. Percentage of patients with elevated NT-proBNP, percentage of patients with abnormal left ventricular function assessed by echocardiography, and association between elevated NT-proBNP and symptoms, signs, and electrocardiography. Results. Using NT-proBNP threshold of 1200 pg/mL, we could detect and confirm chronic heart failure in 5.6% of the study population with concurrent COPD. An elevated level of NT-proBNP was only associated with nocturia and abnormal electrocardiography. Conclusions. We found considerably fewer cases of heart failure in patients with COPD than could be expected from the results of previous studies. Our study shows the need for developing improved strategies to enhance the validity of a suspected heart failure diagnosis in patients with COPD. },
  articleno    = {273864},
  author       = {Kaszuba, Elzbieta and Wagner, Bartlomiej and Odeberg, Håkan and Halling, Anders},
  keyword      = {Chronic obstructive pulmonary disease (COPD),Heart failure,Diagnose,NT-proBNP,echocardiography},
  language     = {eng},
  pages        = {1--5},
  series       = {ISRN Family Medicine},
  title        = {Using NT-proBNP to detect chronic heart failure in elderly patients with chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.5402/2013/273864},
  volume       = {2013},
  year         = {2013},
}