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Investigation of the fetal heart circulation in an animal model using contrast enhanced ultrasound

Jansson, Tomas LU ; Hernandez-Andrade, Edgar LU ; Lingman, Göran LU ; Malcus, Peter LU ; Ley, David LU and Marsal, Karel LU (2005) Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics In Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics p.125-126
Abstract
To assess the distribution of blood from the umbilical vein (UMV), inferior vena cava (IVC) and superior vena cava (SVC) to either side of the fetal lamb heart by using ultrasound enhanced contrast agent imaging. By injection of ultrasound contrast agents (UCA) in UMV, IVC or SVC, the blood from these vessels was tracked, as it then was highly echogenic. By evaluating the image intensity within the heart ventricles, the relative concentrations of blood could be determined. The study was performed in 19 near term fetal lambs of mixed breed, with a mean gestational age of 136 days (range 134-136). Ultrasound contrast agent was injected at a constant rate of 1 ml/min, to ensure that a constant level of contrast agent would be obtained in both... (More)
To assess the distribution of blood from the umbilical vein (UMV), inferior vena cava (IVC) and superior vena cava (SVC) to either side of the fetal lamb heart by using ultrasound enhanced contrast agent imaging. By injection of ultrasound contrast agents (UCA) in UMV, IVC or SVC, the blood from these vessels was tracked, as it then was highly echogenic. By evaluating the image intensity within the heart ventricles, the relative concentrations of blood could be determined. The study was performed in 19 near term fetal lambs of mixed breed, with a mean gestational age of 136 days (range 134-136). Ultrasound contrast agent was injected at a constant rate of 1 ml/min, to ensure that a constant level of contrast agent would be obtained in both sides of the heart. Results: the median percentages of blood distributed to the left ventricle when injecting contrast in UMV, IVC, and SVC, was 68%, 67%, and 21% respectively. These numbers compare well with previously published data, except the recorded percentage distributed from the IVC. This could be a methodological error as well as a result of the mild hypoxia, or an actual increased capacity of the left ventricle at this gestational age (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
image intensity, blood vessel, ultrasound contrast agent, fetal lamb heart, superior vena cava, inferior vena cava, umbilical vein, blood distribution, contrast enhanced ultrasound, fetal heart circulation investigation, animal model, heart ventricle, blood concentration, gestation, hypoxia
in
Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics
pages
125 - 126
publisher
Int. Federation for Medical and Biological Eng
conference name
Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics
ISBN
91-7305-910-2
language
English
LU publication?
yes
id
feffe4be-5675-4629-8023-4272361e8d93 (old id 615263)
date added to LUP
2007-11-25 12:20:52
date last changed
2016-04-16 09:26:39
@inproceedings{feffe4be-5675-4629-8023-4272361e8d93,
  abstract     = {To assess the distribution of blood from the umbilical vein (UMV), inferior vena cava (IVC) and superior vena cava (SVC) to either side of the fetal lamb heart by using ultrasound enhanced contrast agent imaging. By injection of ultrasound contrast agents (UCA) in UMV, IVC or SVC, the blood from these vessels was tracked, as it then was highly echogenic. By evaluating the image intensity within the heart ventricles, the relative concentrations of blood could be determined. The study was performed in 19 near term fetal lambs of mixed breed, with a mean gestational age of 136 days (range 134-136). Ultrasound contrast agent was injected at a constant rate of 1 ml/min, to ensure that a constant level of contrast agent would be obtained in both sides of the heart. Results: the median percentages of blood distributed to the left ventricle when injecting contrast in UMV, IVC, and SVC, was 68%, 67%, and 21% respectively. These numbers compare well with previously published data, except the recorded percentage distributed from the IVC. This could be a methodological error as well as a result of the mild hypoxia, or an actual increased capacity of the left ventricle at this gestational age},
  author       = {Jansson, Tomas and Hernandez-Andrade, Edgar and Lingman, Göran and Malcus, Peter and Ley, David and Marsal, Karel},
  booktitle    = {Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics},
  isbn         = {91-7305-910-2},
  keyword      = {image intensity,blood vessel,ultrasound contrast agent,fetal lamb heart,superior vena cava,inferior vena cava,umbilical vein,blood distribution,contrast enhanced ultrasound,fetal heart circulation investigation,animal model,heart ventricle,blood concentration,gestation,hypoxia},
  language     = {eng},
  pages        = {125--126},
  publisher    = {Int. Federation for Medical and Biological Eng},
  title        = {Investigation of the fetal heart circulation in an animal model using contrast enhanced ultrasound},
  year         = {2005},
}