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Shape determination of microcalcifications in simulated digital mammography images with varying pixel size

Ruschin, Mark LU ; Bath, M ; Hemdal, Bengt LU and Tingberg, Anders LU (2005) Medical Imaging 2005: Image Perception, Observer Performance, and Technology Assessment 5749(1). p.288-299
Abstract
The purpose of this work was to study how the pixel size of digital detectors can affect shape determination of microcalcifications in mammography. Screen-film mammograms containing microcalcifications clinically proven to be indicative of malignancy were digitised at 100 lines/mm using a high-resolution Tango drum scanner. Forty microcalcifications were selected to cover an appropriate range of sizes, shapes and contrasts typically found of malignant cases. Based on the measured MTF and NPS of the combined screen-film and scanner system, these digitised images were filtered to simulate images acquired with a square sampling pixel size of 10 μm × 10 μm and a fill factor of one. To simulate images acquired with larger pixel sizes, these... (More)
The purpose of this work was to study how the pixel size of digital detectors can affect shape determination of microcalcifications in mammography. Screen-film mammograms containing microcalcifications clinically proven to be indicative of malignancy were digitised at 100 lines/mm using a high-resolution Tango drum scanner. Forty microcalcifications were selected to cover an appropriate range of sizes, shapes and contrasts typically found of malignant cases. Based on the measured MTF and NPS of the combined screen-film and scanner system, these digitised images were filtered to simulate images acquired with a square sampling pixel size of 10 μm × 10 μm and a fill factor of one. To simulate images acquired with larger pixel sizes, these finely sampled images were re-binned to yield a range of effective pixel sizes from 20 μm up to 140 μm. An alternative forced-choice (AFC) observer experiment was conducted with eleven observers for this set of digitised microcalcifications to determine how pixel size affects the ability to discriminate shape. It was found that observer score increased with decreasing pixel size down to 60 μm (p<0.01), at which point no significant advantage was obtained by using smaller pixel sizes due to the excessive relative noise-per-pixel. The relative gain in shape discrimination ability at smaller pixel sizes was larger for microcalcifications that were smaller than 500 μm and circular (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
alternative forced-choice observer, fill factor, digitised image filtering, MTF, high-resolution Tango drum scanner, screen-film mammograms, digital detectors, pixel size, simulated digital mammography images, shape determination, microcalcifications, relative noise-per-pixel, shape discrimination, relative gain, image restoration, 20 to 140 micron
host publication
Proceedings of the SPIE - The International Society for Optical Engineering
volume
5749
issue
1
pages
288 - 299
publisher
SPIE
conference name
Medical Imaging 2005: Image Perception, Observer Performance, and Technology Assessment
conference location
San Diego, CA, United States
conference dates
2005-02-15
external identifiers
  • wos:000229068500032
  • other:CODEN: PSISDG
  • scopus:24644479673
ISSN
1996-756X
0277-786X
DOI
10.1117/12.595377
language
English
LU publication?
yes
id
8f3d1ea8-1a32-426b-8521-1ff6d3d5103e (old id 615528)
date added to LUP
2016-04-01 11:40:57
date last changed
2021-03-24 05:19:19
@inproceedings{8f3d1ea8-1a32-426b-8521-1ff6d3d5103e,
  abstract     = {The purpose of this work was to study how the pixel size of digital detectors can affect shape determination of microcalcifications in mammography. Screen-film mammograms containing microcalcifications clinically proven to be indicative of malignancy were digitised at 100 lines/mm using a high-resolution Tango drum scanner. Forty microcalcifications were selected to cover an appropriate range of sizes, shapes and contrasts typically found of malignant cases. Based on the measured MTF and NPS of the combined screen-film and scanner system, these digitised images were filtered to simulate images acquired with a square sampling pixel size of 10 μm × 10 μm and a fill factor of one. To simulate images acquired with larger pixel sizes, these finely sampled images were re-binned to yield a range of effective pixel sizes from 20 μm up to 140 μm. An alternative forced-choice (AFC) observer experiment was conducted with eleven observers for this set of digitised microcalcifications to determine how pixel size affects the ability to discriminate shape. It was found that observer score increased with decreasing pixel size down to 60 μm (p&lt;0.01), at which point no significant advantage was obtained by using smaller pixel sizes due to the excessive relative noise-per-pixel. The relative gain in shape discrimination ability at smaller pixel sizes was larger for microcalcifications that were smaller than 500 μm and circular},
  author       = {Ruschin, Mark and Bath, M and Hemdal, Bengt and Tingberg, Anders},
  booktitle    = {Proceedings of the SPIE - The International Society for Optical Engineering},
  issn         = {1996-756X},
  language     = {eng},
  number       = {1},
  pages        = {288--299},
  publisher    = {SPIE},
  title        = {Shape determination of microcalcifications in simulated digital mammography images with varying pixel size},
  url          = {http://dx.doi.org/10.1117/12.595377},
  doi          = {10.1117/12.595377},
  volume       = {5749},
  year         = {2005},
}