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Indentation testing of a bone defect filled with two different injectable bone substitutes

Wang, Jian-Sheng LU ; Tanner, K; Abdulghani, Saba LU and Lidgren, Lars LU (2005) 17th International Symposium on Ceramics in Medicine. The Annual Meeting of the International Society for Ceramics in Medicine In Key Engineering Materials 284-286. p.89-92
Abstract
Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to a higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect.... (More)
Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to a higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect. With IBS-2, new bone grew into the outer 0.5-1.0 mm. The materials could be used for different indications, such as to support fracture healing or in contained cavities (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
CaPO<sub>4</sub>, cavities, fracture healing, histology evaluation, bone defect, indentation testing, injectable bone substitutes, calcium phosphate, calcium sulphate, bone integration, CaSO<sub>4</sub>, mechanical loading, hydroxyapatite, femur, rabbits, tibia
in
Key Engineering Materials
volume
284-286
pages
89 - 92
publisher
Trans Tech Publications Ltd
conference name
17th International Symposium on Ceramics in Medicine. The Annual Meeting of the International Society for Ceramics in Medicine
external identifiers
  • scopus:34248994283
ISSN
1013-9826
DOI
10.4028/www.scientific.net/KEM.284-286.89
language
English
LU publication?
yes
id
94549e79-c660-4405-8d88-732edfd77693 (old id 615569)
date added to LUP
2007-11-25 17:31:45
date last changed
2017-01-01 07:06:08
@inproceedings{94549e79-c660-4405-8d88-732edfd77693,
  abstract     = {Injectable bone substitutes (IBS) based on calcium phosphate (CaP) and/or calcium sulphate (CaS) are used as fillers in bone defects to stimulate bone integration and allow mechanical loading. Two types of IBS, IBS-1 is CaP+20%CaS and IBS-2 is CaS+40% hydroxyapatite, were investigated. The materials were injected into holes in the femur and tibia in rabbits. After 10 weeks the femora were subjected to indentation testing and tibiae were prepared for histology evaluation. IBS-1 lead to a higher indentation load compared to control, that is no material inserted, while IBS-2 showed no significant difference between material and control. Histology showed that with IBS-1, the bone penetrated into and integrated with the material in the defect. With IBS-2, new bone grew into the outer 0.5-1.0 mm. The materials could be used for different indications, such as to support fracture healing or in contained cavities},
  author       = {Wang, Jian-Sheng and Tanner, K and Abdulghani, Saba and Lidgren, Lars},
  booktitle    = {Key Engineering Materials},
  issn         = {1013-9826},
  keyword      = {CaPO<sub>4</sub>,cavities,fracture healing,histology evaluation,bone defect,indentation testing,injectable bone substitutes,calcium phosphate,calcium sulphate,bone integration,CaSO<sub>4</sub>,mechanical loading,hydroxyapatite,femur,rabbits,tibia},
  language     = {eng},
  pages        = {89--92},
  publisher    = {Trans Tech Publications Ltd},
  title        = {Indentation testing of a bone defect filled with two different injectable bone substitutes},
  url          = {http://dx.doi.org/10.4028/www.scientific.net/KEM.284-286.89},
  volume       = {284-286},
  year         = {2005},
}