No evidence of association of the PDCD1 gene with Type 1 diabetes
Fawwaz, S. ; Nikamo, P. ; Törn, Carina LU ; Landin-Olsson, Mona LU ; Lernmark, Åke LU
; Alarcon-Riquelme, M.
and Kockum, I.
(2007)
In Diabetic Medicine
24(12).
p.1473-1477
- Abstract
- Aims To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738. Results We did not... (More)
- Aims To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738. Results We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association. Conclusions We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/968906
- author
- Fawwaz, S.
; Nikamo, P.
; Törn, Carina
LU
; Landin-Olsson, Mona
LU
; Lernmark, Åke
LU
; Alarcon-Riquelme, M.
and Kockum, I.
- author collaboration
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Type 1 diabetes, PDCD1, association, autoimmunity
- in
- Diabetic Medicine
- volume
- 24
- issue
- 12
- pages
- 1473 - 1477
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000251250200026
- scopus:36549074537
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2007.02297.x
- language
- English
- LU publication?
- no
- id
- 615ce61a-1028-4abe-a05f-2300ba4139b6 (old id 968906)
- date added to LUP
- 2016-04-01 16:30:15
- date last changed
- 2024-01-26 07:06:32
@article{615ce61a-1028-4abe-a05f-2300ba4139b6,
abstract = {{Aims To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738. Results We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association. Conclusions We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.}},
author = {{Fawwaz, S. and Nikamo, P. and Törn, Carina and Landin-Olsson, Mona and Lernmark, Åke and Alarcon-Riquelme, M. and Kockum, I.}},
issn = {{1464-5491}},
keywords = {{Type 1 diabetes; PDCD1; association; autoimmunity}},
language = {{eng}},
number = {{12}},
pages = {{1473--1477}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{No evidence of association of the PDCD1 gene with Type 1 diabetes}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2007.02297.x}},
doi = {{10.1111/j.1464-5491.2007.02297.x}},
volume = {{24}},
year = {{2007}},
}