Advanced

Influences of Endogenous and Exogenous Hormones in Middle-aged Women

Khatibi Esfanjani, Ali LU (2007) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2007 162.
Abstract
Endogenous and exogenous sex hormones are of pivotal importance for women’s health. Hormone therapy has been widely studied but there is limited data about androgen and androgen replacement therapy.

The aim of this study was to delineate the possible interrelations between endogenous androgens and women’s particularly pertaining to cardiovascular disease (CVD) and risk markers for CVD in perimenopausal women.



A total of 6917 out of 10766 women aged 50-59 years living in the Lund area of southern Sweden completed a generic questionnaire and underwent physical examination and laboratory assessments. According to the hormonal status, 492 (7.1%) were classified as pre-menopausal with regular menstruation, 3600... (More)
Endogenous and exogenous sex hormones are of pivotal importance for women’s health. Hormone therapy has been widely studied but there is limited data about androgen and androgen replacement therapy.

The aim of this study was to delineate the possible interrelations between endogenous androgens and women’s particularly pertaining to cardiovascular disease (CVD) and risk markers for CVD in perimenopausal women.



A total of 6917 out of 10766 women aged 50-59 years living in the Lund area of southern Sweden completed a generic questionnaire and underwent physical examination and laboratory assessments. According to the hormonal status, 492 (7.1%) were classified as pre-menopausal with regular menstruation, 3600 (52.1%) were postmenopausal without hormone therapy (HT) and 2816 (40.8%) were postmenopausal women with use of HT.

There were 104 women with reported cardiovascular events, each of them were matched to two controls (n=208).



Use of hormone therapy and higher serum androgens were accompanied by a lower risk profile for CVD. Women with higher serum androgen (but in the normal range) had more favourable lipid profile. Hormone therapy in women with abnormal serum thyroid stimulating hormone (TSH) seems to improve the lipid profile.

Endogenous androgens seem to have a dual influence (both vasodilatatoy and vasoconstrictory) on women’s blood pressure depending on women’s health status.

Women with lower androgens used more non-hormonal medication and visited health care units more often. Hormone therapy seems to be associated with allergic and upper gastrointestinal problems in postmenopausal women. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • PhD van der Schouw, Yvonne T, University Medical Center Utrecht
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Lipid profile, Blood pressure, Non-hormonal drug, Middle-aged women, Cardiovascular disease, Menopause, Androstendione, Androgen, Testosterone
in
Lund University, Faculty of Medicine Doctoral Dissertation Series 2007
volume
162
pages
134 pages
publisher
Department of Obstetrics and Gynecology, Lund University
defense location
Förläsningssalen ,Plan 3, Kvinnokliniken i Lund
defense date
2007-12-06 14:00
ISSN
1652-8220
ISBN
978-91-85897-40-7
project
The Women's Health in Lund Area (WHILA)
language
English
LU publication?
yes
id
2850da76-2303-4a15-ac2f-a05b128eebc2 (old id 617495)
date added to LUP
2007-11-20 14:20:05
date last changed
2016-09-19 08:44:54
@phdthesis{2850da76-2303-4a15-ac2f-a05b128eebc2,
  abstract     = {Endogenous and exogenous sex hormones are of pivotal importance for women’s health. Hormone therapy has been widely studied but there is limited data about androgen and androgen replacement therapy. <br/><br>
The aim of this study was to delineate the possible interrelations between endogenous androgens and women’s particularly pertaining to cardiovascular disease (CVD) and risk markers for CVD in perimenopausal women.<br/><br>
<br/><br>
A total of 6917 out of 10766 women aged 50-59 years living in the Lund area of southern Sweden completed a generic questionnaire and underwent physical examination and laboratory assessments. According to the hormonal status, 492 (7.1%) were classified as pre-menopausal with regular menstruation, 3600 (52.1%) were postmenopausal without hormone therapy (HT) and 2816 (40.8%) were postmenopausal women with use of HT. <br/><br>
There were 104 women with reported cardiovascular events, each of them were matched to two controls (n=208). <br/><br>
<br/><br>
Use of hormone therapy and higher serum androgens were accompanied by a lower risk profile for CVD. Women with higher serum androgen (but in the normal range) had more favourable lipid profile. Hormone therapy in women with abnormal serum thyroid stimulating hormone (TSH) seems to improve the lipid profile. <br/><br>
Endogenous androgens seem to have a dual influence (both vasodilatatoy and vasoconstrictory) on women’s blood pressure depending on women’s health status. <br/><br>
Women with lower androgens used more non-hormonal medication and visited health care units more often. Hormone therapy seems to be associated with allergic and upper gastrointestinal problems in postmenopausal women.},
  author       = {Khatibi Esfanjani, Ali},
  isbn         = {978-91-85897-40-7},
  issn         = {1652-8220},
  keyword      = {Lipid profile,Blood pressure,Non-hormonal drug,Middle-aged women,Cardiovascular disease,Menopause,Androstendione,Androgen,Testosterone},
  language     = {eng},
  pages        = {134},
  publisher    = {Department of Obstetrics and Gynecology, Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series 2007},
  title        = {Influences of Endogenous and Exogenous Hormones in Middle-aged Women},
  volume       = {162},
  year         = {2007},
}