Huntington's disease: a synaptopathy?
(2003) In Trends in Molecular Medicine 9(10). p.414-420- Abstract
- Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin. In its terminal stage, HD is characterized by widespread neuronal death in the neocortex and the striatum. Classically, this neuronal death has been thought to underlie most of the symptoms of the disease. Accumulating evidence suggests, however, that cellular dysfunction is important in the pathogenesis of HD. We propose that specific impairment of the exocytosis and endocytosis machinery contributes to the development of HD. We also suggest that abnormal synaptic transmission underlies the early symptoms of HD and can contribute to the triggering of cell death in later stages of the disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/118286
- author
- Li, Jia-Yi LU ; Plomann, Markus and Brundin, Patrik LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Molecular Medicine
- volume
- 9
- issue
- 10
- pages
- 414 - 420
- publisher
- Elsevier
- external identifiers
-
- pmid:14557053
- wos:000186206800005
- scopus:0142184100
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2003.08.006
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neural Plasticity and Repair (013210080)
- id
- 61855709-2d6f-4ecf-9ade-78d58cc5cf80 (old id 118286)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14557053&dopt=Abstract
- date added to LUP
- 2016-04-01 16:30:28
- date last changed
- 2022-04-22 22:29:36
@article{61855709-2d6f-4ecf-9ade-78d58cc5cf80, abstract = {{Huntington's disease (HD) is caused by a polyglutamine expansion in the protein huntingtin. In its terminal stage, HD is characterized by widespread neuronal death in the neocortex and the striatum. Classically, this neuronal death has been thought to underlie most of the symptoms of the disease. Accumulating evidence suggests, however, that cellular dysfunction is important in the pathogenesis of HD. We propose that specific impairment of the exocytosis and endocytosis machinery contributes to the development of HD. We also suggest that abnormal synaptic transmission underlies the early symptoms of HD and can contribute to the triggering of cell death in later stages of the disease.}}, author = {{Li, Jia-Yi and Plomann, Markus and Brundin, Patrik}}, issn = {{1471-4914}}, language = {{eng}}, number = {{10}}, pages = {{414--420}}, publisher = {{Elsevier}}, series = {{Trends in Molecular Medicine}}, title = {{Huntington's disease: a synaptopathy?}}, url = {{http://dx.doi.org/10.1016/j.molmed.2003.08.006}}, doi = {{10.1016/j.molmed.2003.08.006}}, volume = {{9}}, year = {{2003}}, }