Microstructural characterization and in vitro bioactivity of porous glass-ceramic scaffolds for bone regeneration by synchrotron radiation X-ray microtomography
Renghini, Chiara ; Giuliani, Alessandra ; Mazzoni, Serena ; Brun, Francesco ; Larsson, Emanuel LU
; Baino, Francesco
and Vitale-Brovarone, Chiara
(2013)
In Journal of the European Ceramic Society
33(9).
p.1553-1565
- Abstract
One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are carried out on Bioglass®- and CEL2-derived scaffolds produced by sponge replication (CEL2 is an experimental glass developed at Politecnico di Torino). Synchrotron radiation X-ray microtomography is used to study the samples 3-D architecture, pores size, shape, distribution and interconnectivity, as well as the growth kinetics on... (More)
One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are carried out on Bioglass®- and CEL2-derived scaffolds produced by sponge replication (CEL2 is an experimental glass developed at Politecnico di Torino). Synchrotron radiation X-ray microtomography is used to study the samples 3-D architecture, pores size, shape, distribution and interconnectivity, as well as the growth kinetics on scaffolds struts of a newly formed apatitic phase during in vitro treatment in simulated body fluid, in order to describe from a quantitative viewpoint the bioactive potential of the analyzed biomaterials. An accurate comparison between architectural features and bioactive behaviour of Bioglass®- and CEL2-derived scaffolds is presented and discussed.
(Less)
- author
- Renghini, Chiara
; Giuliani, Alessandra
; Mazzoni, Serena
; Brun, Francesco
; Larsson, Emanuel
LU
; Baino, Francesco
and Vitale-Brovarone, Chiara
- publishing date
- 2013-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Bone tissue engineering, Glass-ceramic scaffold, In vitro bioactivity, Sponge replication, X-ray microtomography
- in
- Journal of the European Ceramic Society
- volume
- 33
- issue
- 9
- pages
- 1553 - 1565
- publisher
- Elsevier
- external identifiers
-
- scopus:84875947688
- ISSN
- 0955-2219
- DOI
- 10.1016/j.jeurceramsoc.2012.10.016
- language
- English
- LU publication?
- no
- id
- 61a39f82-899c-468a-9b11-cfd3a1bb5241
- date added to LUP
- 2025-08-26 11:24:11
- date last changed
- 2025-08-26 12:04:11
@article{61a39f82-899c-468a-9b11-cfd3a1bb5241,
abstract = {{<p>One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are carried out on Bioglass<sup>®</sup>- and CEL2-derived scaffolds produced by sponge replication (CEL2 is an experimental glass developed at Politecnico di Torino). Synchrotron radiation X-ray microtomography is used to study the samples 3-D architecture, pores size, shape, distribution and interconnectivity, as well as the growth kinetics on scaffolds struts of a newly formed apatitic phase during in vitro treatment in simulated body fluid, in order to describe from a quantitative viewpoint the bioactive potential of the analyzed biomaterials. An accurate comparison between architectural features and bioactive behaviour of Bioglass<sup>®</sup>- and CEL2-derived scaffolds is presented and discussed.</p>}},
author = {{Renghini, Chiara and Giuliani, Alessandra and Mazzoni, Serena and Brun, Francesco and Larsson, Emanuel and Baino, Francesco and Vitale-Brovarone, Chiara}},
issn = {{0955-2219}},
keywords = {{Bone tissue engineering; Glass-ceramic scaffold; In vitro bioactivity; Sponge replication; X-ray microtomography}},
language = {{eng}},
number = {{9}},
pages = {{1553--1565}},
publisher = {{Elsevier}},
series = {{Journal of the European Ceramic Society}},
title = {{Microstructural characterization and in vitro bioactivity of porous glass-ceramic scaffolds for bone regeneration by synchrotron radiation X-ray microtomography}},
url = {{http://dx.doi.org/10.1016/j.jeurceramsoc.2012.10.016}},
doi = {{10.1016/j.jeurceramsoc.2012.10.016}},
volume = {{33}},
year = {{2013}},
}