Bringing Advanced Therapies for Parkinson's Disease to the Clinic : The Scientist's Perspective
(2021) In Journal of Parkinson's Disease 11(s2). p.135-140- Abstract
After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where the functionality and safety of these products will need to stand the test in clinical trials. If successful, these new products can have the potential to provide patients with a one-time administered treatment which may alleviate them from daily symptomatic dopaminergic medication.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/61b97542-cb89-4ec1-9a46-96eb786f8db1
- author
- Tomishima, Mark and Kirkeby, Agnete LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ATMP, clinical trial, dopaminergic neurons, regenerative therapy, stem cells, transplantation
- in
- Journal of Parkinson's Disease
- volume
- 11
- issue
- s2
- pages
- 135 - 140
- publisher
- IOS Press
- external identifiers
-
- scopus:85116015714
- pmid:34250954
- ISSN
- 1877-7171
- DOI
- 10.3233/jpd-212685
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 - The authors. Published by IOS Press.
- id
- 61b97542-cb89-4ec1-9a46-96eb786f8db1
- date added to LUP
- 2021-10-25 10:52:33
- date last changed
- 2024-09-22 04:00:45
@article{61b97542-cb89-4ec1-9a46-96eb786f8db1, abstract = {{<p>After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where the functionality and safety of these products will need to stand the test in clinical trials. If successful, these new products can have the potential to provide patients with a one-time administered treatment which may alleviate them from daily symptomatic dopaminergic medication.</p>}}, author = {{Tomishima, Mark and Kirkeby, Agnete}}, issn = {{1877-7171}}, keywords = {{ATMP; clinical trial; dopaminergic neurons; regenerative therapy; stem cells; transplantation}}, language = {{eng}}, number = {{s2}}, pages = {{135--140}}, publisher = {{IOS Press}}, series = {{Journal of Parkinson's Disease}}, title = {{Bringing Advanced Therapies for Parkinson's Disease to the Clinic : The Scientist's Perspective}}, url = {{http://dx.doi.org/10.3233/jpd-212685}}, doi = {{10.3233/jpd-212685}}, volume = {{11}}, year = {{2021}}, }