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Early screening outcomes before, during, and after a randomized controlled trial with digital breast tomosynthesis

Holen, Åsne Sørlien ; Bergan, Marie Burns ; Lee, Christoph I. ; Zackrisson, Sophia LU ; Moshina, Nataliia ; Aase, Hildegunn Siv ; Haldorsen, Ingfrid Salvesen and Hofvind, Solveig (2023) In European Journal of Radiology 167.
Abstract

Purpose: To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography (DM) (To-Be 1) and a follow-up cohort study using DBT (To-Be 2). Methods: Retrospective results of 125,020 screening examinations from four consecutive screening rounds performed in 2014–2021 were described and compared for pre-To-Be 1 (DM), To-Be 1 (DM or DBT), To-Be 2 (DBT), and post-To-Be 2 (DM) cohorts. Descriptive analyses of rates of recall, biopsy, screen-detected and interval cancer, distribution of histopathologic tumor characteristics and time spent on image interpretation and consensus were presented for... (More)

Purpose: To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography (DM) (To-Be 1) and a follow-up cohort study using DBT (To-Be 2). Methods: Retrospective results of 125,020 screening examinations from four consecutive screening rounds performed in 2014–2021 were described and compared for pre-To-Be 1 (DM), To-Be 1 (DM or DBT), To-Be 2 (DBT), and post-To-Be 2 (DM) cohorts. Descriptive analyses of rates of recall, biopsy, screen-detected and interval cancer, distribution of histopathologic tumor characteristics and time spent on image interpretation and consensus were presented for the four rounds including five cohorts, one cohort in each screening round except for the To-Be 1 trail, which included a DBT and a DM cohort. Odds ratios (OR) with 95% CIs was calculated for recall and cancer detection rates. Results: Rate of screen-detected cancer was 0.90% for women screened with DBT in To-Be 2 and 0.64% for DM in pre-To-Be 1. The rates did not differ for the To-Be 1 DM (0.61%), To-Be 1 DBT (0.66%) and post-To-Be 2 DM (0.67%) cohorts. The interval cancer rates ranged between 0.13% and 0.20%. The distribution of histopathologic tumor characteristics did not differ between the cohorts. Conclusions: Screening all women with DBT following a randomized controlled trial in an organized, population-based screening program showed a temporary increase in the rate of screen-detected cancer.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast neoplasm, Digital breast tomosynthesis, Digital mammography, Mass screening, Randomized controlled trial
in
European Journal of Radiology
volume
167
article number
111069
publisher
Elsevier
external identifiers
  • pmid:37708674
  • scopus:85170687248
ISSN
0720-048X
DOI
10.1016/j.ejrad.2023.111069
language
English
LU publication?
yes
id
61bf1ba6-6392-41f0-94f2-3612cda35ecf
date added to LUP
2023-12-06 09:13:08
date last changed
2024-04-19 03:45:20
@article{61bf1ba6-6392-41f0-94f2-3612cda35ecf,
  abstract     = {{<p>Purpose: To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography (DM) (To-Be 1) and a follow-up cohort study using DBT (To-Be 2). Methods: Retrospective results of 125,020 screening examinations from four consecutive screening rounds performed in 2014–2021 were described and compared for pre-To-Be 1 (DM), To-Be 1 (DM or DBT), To-Be 2 (DBT), and post-To-Be 2 (DM) cohorts. Descriptive analyses of rates of recall, biopsy, screen-detected and interval cancer, distribution of histopathologic tumor characteristics and time spent on image interpretation and consensus were presented for the four rounds including five cohorts, one cohort in each screening round except for the To-Be 1 trail, which included a DBT and a DM cohort. Odds ratios (OR) with 95% CIs was calculated for recall and cancer detection rates. Results: Rate of screen-detected cancer was 0.90% for women screened with DBT in To-Be 2 and 0.64% for DM in pre-To-Be 1. The rates did not differ for the To-Be 1 DM (0.61%), To-Be 1 DBT (0.66%) and post-To-Be 2 DM (0.67%) cohorts. The interval cancer rates ranged between 0.13% and 0.20%. The distribution of histopathologic tumor characteristics did not differ between the cohorts. Conclusions: Screening all women with DBT following a randomized controlled trial in an organized, population-based screening program showed a temporary increase in the rate of screen-detected cancer.</p>}},
  author       = {{Holen, Åsne Sørlien and Bergan, Marie Burns and Lee, Christoph I. and Zackrisson, Sophia and Moshina, Nataliia and Aase, Hildegunn Siv and Haldorsen, Ingfrid Salvesen and Hofvind, Solveig}},
  issn         = {{0720-048X}},
  keywords     = {{Breast neoplasm; Digital breast tomosynthesis; Digital mammography; Mass screening; Randomized controlled trial}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Radiology}},
  title        = {{Early screening outcomes before, during, and after a randomized controlled trial with digital breast tomosynthesis}},
  url          = {{http://dx.doi.org/10.1016/j.ejrad.2023.111069}},
  doi          = {{10.1016/j.ejrad.2023.111069}},
  volume       = {{167}},
  year         = {{2023}},
}