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Clinical outcomes of no stenting in patients with ST-segment elevation myocardial infarction undergoing deferred primary percutaneous coronary intervention

Madsen, Jasmine Melissa ; Kelbæk, Henning ; Nepper-Christensen, Lars ; Jacobsen, Mia Ravn ; Ahtarovski, Kiril Aleksov ; Høfsten, Dan Eik ; Holmvang, Lene ; Pedersen, Frants ; Tilsted, Hans Henrik and Aarøe, Jens , et al. (2022) In EuroIntervention 18(6). p.482-491
Abstract

Background: ST-segment elevation myocardial infarction (STEMI) is treated with stenting, but the underlying stenosis is often not severe, and stenting may potentially be omitted. Aims: The aim of the study was to investigate outcomes of patients with STEMI treated with percutaneous coronary intervention (PCI) without stenting. Methods: Patients were identified through the DANAMI-3-DEFER study. Stenting was omitted in the patients with stable flow after initial PCI and no significant residual stenosis on the deferral procedure, who were randomised to deferred stenting. These patients were compared to patients randomised to conventional PCI treated with immediate stenting. The primary endpoint was a composite of all-cause mortality,... (More)

Background: ST-segment elevation myocardial infarction (STEMI) is treated with stenting, but the underlying stenosis is often not severe, and stenting may potentially be omitted. Aims: The aim of the study was to investigate outcomes of patients with STEMI treated with percutaneous coronary intervention (PCI) without stenting. Methods: Patients were identified through the DANAMI-3-DEFER study. Stenting was omitted in the patients with stable flow after initial PCI and no significant residual stenosis on the deferral procedure, who were randomised to deferred stenting. These patients were compared to patients randomised to conventional PCI treated with immediate stenting. The primary endpoint was a composite of all-cause mortality, recurrent myocardial infarction (MI), and target vessel revascularisation (TVR). Results: Of 603 patients randomised to deferred stenting, 84 were treated without stenting, and in patients randomised to conventional PCI (n=612), 590 were treated with immediate stenting. Patients treated with no stenting had a median stenosis of 40%, median vessel diameter of 2.9 mm, and median lesion length of 11.4 mm. During a median follow-up of 3.4 years, the composite endpoint occurred in 14% and 16% in the no and immediate stenting groups, respectively (unadjusted hazard ratio [HR] 0.87, 95% confidence interval [CI]: 0.48-1.60; p=0.66). The association remained non-significant after adjusting for confounders (adjusted HR 0.53, 95% CI: 0.22-1.24; p=0.14). The rates of TVR and recurrent MI were 2% vs 4% (p=0.70) and 4% vs 6% (p=0.43), respectively. Conclusions: Patients with STEMI, with no significant residual stenosis and stable flow after initial PCI, treated without stenting, had comparable event rates to patients treated with immediate stenting.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
plaque rupture, risk stratification, STEMI
in
EuroIntervention
volume
18
issue
6
pages
10 pages
publisher
Société Europa Edition
external identifiers
  • scopus:85134765835
  • pmid:35289303
ISSN
1774-024X
DOI
10.4244/EIJ-D-21-00950
language
English
LU publication?
yes
id
61d4b598-44ae-4ac4-8c95-0221f42fabc2
date added to LUP
2023-01-03 15:35:31
date last changed
2024-06-13 16:13:56
@article{61d4b598-44ae-4ac4-8c95-0221f42fabc2,
  abstract     = {{<p>Background: ST-segment elevation myocardial infarction (STEMI) is treated with stenting, but the underlying stenosis is often not severe, and stenting may potentially be omitted. Aims: The aim of the study was to investigate outcomes of patients with STEMI treated with percutaneous coronary intervention (PCI) without stenting. Methods: Patients were identified through the DANAMI-3-DEFER study. Stenting was omitted in the patients with stable flow after initial PCI and no significant residual stenosis on the deferral procedure, who were randomised to deferred stenting. These patients were compared to patients randomised to conventional PCI treated with immediate stenting. The primary endpoint was a composite of all-cause mortality, recurrent myocardial infarction (MI), and target vessel revascularisation (TVR). Results: Of 603 patients randomised to deferred stenting, 84 were treated without stenting, and in patients randomised to conventional PCI (n=612), 590 were treated with immediate stenting. Patients treated with no stenting had a median stenosis of 40%, median vessel diameter of 2.9 mm, and median lesion length of 11.4 mm. During a median follow-up of 3.4 years, the composite endpoint occurred in 14% and 16% in the no and immediate stenting groups, respectively (unadjusted hazard ratio [HR] 0.87, 95% confidence interval [CI]: 0.48-1.60; p=0.66). The association remained non-significant after adjusting for confounders (adjusted HR 0.53, 95% CI: 0.22-1.24; p=0.14). The rates of TVR and recurrent MI were 2% vs 4% (p=0.70) and 4% vs 6% (p=0.43), respectively. Conclusions: Patients with STEMI, with no significant residual stenosis and stable flow after initial PCI, treated without stenting, had comparable event rates to patients treated with immediate stenting.</p>}},
  author       = {{Madsen, Jasmine Melissa and Kelbæk, Henning and Nepper-Christensen, Lars and Jacobsen, Mia Ravn and Ahtarovski, Kiril Aleksov and Høfsten, Dan Eik and Holmvang, Lene and Pedersen, Frants and Tilsted, Hans Henrik and Aarøe, Jens and Jensen, Svend Eggert and Raungaard, Bent and Terkelsen, Christian Juhl and Køber, Lars and Engstrøm, Thomas and Lønborg, Jacob Thomsen}},
  issn         = {{1774-024X}},
  keywords     = {{plaque rupture; risk stratification; STEMI}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{482--491}},
  publisher    = {{Société Europa Edition}},
  series       = {{EuroIntervention}},
  title        = {{Clinical outcomes of no stenting in patients with ST-segment elevation myocardial infarction undergoing deferred primary percutaneous coronary intervention}},
  url          = {{http://dx.doi.org/10.4244/EIJ-D-21-00950}},
  doi          = {{10.4244/EIJ-D-21-00950}},
  volume       = {{18}},
  year         = {{2022}},
}