Obesity and asthma: current knowledge and future needs
(2015) In Current Opinion in Pulmonary Medicine 21(1). p.80-85- Abstract
- Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies... (More)
- Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma. Summary Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4950719
- author
- Sivapalan, Pradeesh ; Diamant, Zuzana LU and Ulrik, Charlotte Suppli
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- asthma, asthma control, inflammation, mechanism, obesity, phenotype, quality of life
- in
- Current Opinion in Pulmonary Medicine
- volume
- 21
- issue
- 1
- pages
- 80 - 85
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000345912400012
- scopus:84918503168
- pmid:25405670
- ISSN
- 1531-6971
- DOI
- 10.1097/MCP.0000000000000119
- language
- English
- LU publication?
- yes
- id
- 61e468be-7199-467f-b176-6b45245ca1aa (old id 4950719)
- date added to LUP
- 2016-04-01 11:07:30
- date last changed
- 2022-02-10 17:00:37
@article{61e468be-7199-467f-b176-6b45245ca1aa,
abstract = {{Purpose of review Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction. Recent findings Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma. Summary Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group.}},
author = {{Sivapalan, Pradeesh and Diamant, Zuzana and Ulrik, Charlotte Suppli}},
issn = {{1531-6971}},
keywords = {{asthma; asthma control; inflammation; mechanism; obesity; phenotype; quality of life}},
language = {{eng}},
number = {{1}},
pages = {{80--85}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Pulmonary Medicine}},
title = {{Obesity and asthma: current knowledge and future needs}},
url = {{http://dx.doi.org/10.1097/MCP.0000000000000119}},
doi = {{10.1097/MCP.0000000000000119}},
volume = {{21}},
year = {{2015}},
}