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Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes

Sato, Yuki; Nagao, Mototsugu LU ; Asai, Akira; Nakajima, Yasushi; Takaya, Makiyo; Takeichi-Hattori, Naomi; Takemitsu, Shuji; Sudo, Mariko; Kano-Wakakuri, Toshiko and Ishizaki, Akira, et al. (2013) In Journal of Diabetes Investigation 4(6). p.634-639
Abstract

Aims/Introduction: Postprandial hyperglycemia is a potent risk factor for cardiovascular disease. Serum glycated albumin (GA) has been reported to reflect postprandial blood glucose fluctuations. In the present study, we assessed the possible correlation of GA with the presence of carotid plaque to evaluate the potential clinical usefulness of GA for predicting atherosclerotic cardiovascular complications in patients with type 2 diabetes. Materials and Methods: Patients with type 2 diabetes (n = 236) admitted to Nippon Medical School Hospital (Tokyo, Japan) for glycemic control (aged 19-86 years, 81 females and 155 males) were examined. Clinical measurements were taken on admission. The presence of carotid plaque was assessed by... (More)

Aims/Introduction: Postprandial hyperglycemia is a potent risk factor for cardiovascular disease. Serum glycated albumin (GA) has been reported to reflect postprandial blood glucose fluctuations. In the present study, we assessed the possible correlation of GA with the presence of carotid plaque to evaluate the potential clinical usefulness of GA for predicting atherosclerotic cardiovascular complications in patients with type 2 diabetes. Materials and Methods: Patients with type 2 diabetes (n = 236) admitted to Nippon Medical School Hospital (Tokyo, Japan) for glycemic control (aged 19-86 years, 81 females and 155 males) were examined. Clinical measurements were taken on admission. The presence of carotid plaque was assessed by ultrasonography. Results: In patients with carotid plaque (n = 154), GA (P = 0.023) was higher than those without carotid plaque (n = 82). In contrast, neither fasting plasma glucose (P = 0.48) nor glycated hemoglobin (P = 0.41) was significantly different between the groups. The results of logistic regression analysis showed that GA (age- and sex-adjusted odds ratio [95% confidence interval], 1.05 [1.01-1.09]; P = 0.017) and glycated hemoglobin (1.17 [1.01-1.37]; P = 0.036) were significantly associated with the presence of carotid plaque. Conclusions: The positive correlation of serum GA with the presence of carotid plaque in type 2 diabetes suggests that GA will serve as a useful clinical marker for predicting diabetic cardiovascular complications.

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type
Contribution to journal
publication status
published
subject
keywords
Carotid plaque, Glycated albumin, Type 2 diabetes mellitus
in
Journal of Diabetes Investigation
volume
4
issue
6
pages
634 - 639
publisher
Wiley-Blackwell
external identifiers
  • scopus:84888436502
ISSN
2040-1116
DOI
10.1111/jdi.12085
language
English
LU publication?
no
id
61e69346-e785-4c68-be96-d5145839ea11
date added to LUP
2017-08-23 20:02:43
date last changed
2018-01-11 11:20:17
@article{61e69346-e785-4c68-be96-d5145839ea11,
  abstract     = {<p>Aims/Introduction: Postprandial hyperglycemia is a potent risk factor for cardiovascular disease. Serum glycated albumin (GA) has been reported to reflect postprandial blood glucose fluctuations. In the present study, we assessed the possible correlation of GA with the presence of carotid plaque to evaluate the potential clinical usefulness of GA for predicting atherosclerotic cardiovascular complications in patients with type 2 diabetes. Materials and Methods: Patients with type 2 diabetes (n = 236) admitted to Nippon Medical School Hospital (Tokyo, Japan) for glycemic control (aged 19-86 years, 81 females and 155 males) were examined. Clinical measurements were taken on admission. The presence of carotid plaque was assessed by ultrasonography. Results: In patients with carotid plaque (n = 154), GA (P = 0.023) was higher than those without carotid plaque (n = 82). In contrast, neither fasting plasma glucose (P = 0.48) nor glycated hemoglobin (P = 0.41) was significantly different between the groups. The results of logistic regression analysis showed that GA (age- and sex-adjusted odds ratio [95% confidence interval], 1.05 [1.01-1.09]; P = 0.017) and glycated hemoglobin (1.17 [1.01-1.37]; P = 0.036) were significantly associated with the presence of carotid plaque. Conclusions: The positive correlation of serum GA with the presence of carotid plaque in type 2 diabetes suggests that GA will serve as a useful clinical marker for predicting diabetic cardiovascular complications.</p>},
  author       = {Sato, Yuki and Nagao, Mototsugu and Asai, Akira and Nakajima, Yasushi and Takaya, Makiyo and Takeichi-Hattori, Naomi and Takemitsu, Shuji and Sudo, Mariko and Kano-Wakakuri, Toshiko and Ishizaki, Akira and Harada, Taro and Tanimura-Inagaki, Kyoko and Okajima, Fumitaka and Tamura, Hideki and Sugihara, Hitoshi and Oikawa, Shinichi},
  issn         = {2040-1116},
  keyword      = {Carotid plaque,Glycated albumin,Type 2 diabetes mellitus},
  language     = {eng},
  number       = {6},
  pages        = {634--639},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Diabetes Investigation},
  title        = {Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes},
  url          = {http://dx.doi.org/10.1111/jdi.12085},
  volume       = {4},
  year         = {2013},
}