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Prolactin level during 5 years of risperidone treatment in patients with psychotic disorders.

Eberhard, Jonas LU ; Lindström, E; Holstad, M. and Levander, Sten LU (2007) In Acta Psychiatrica Scandinavica 115(4). p.268-276
Abstract
Objective: To investigate prolactin levels and related side effects in 128 men and 90 women initially treated with risperidone. Method: Patients initially treated with risperidone were followed over 5 years, during which 45% were switched to other antipsychotic drugs. Results: Initially, prolactin levels were fivefold the norm in women, and threefold in men. Diagnosis did not affect the prolactin level if adjustment for sex, current age, and age at onset of psychosis was applied. Prolactin levels did not correlate significantly neither with any Positive and Negative Symptom Scale item or subscale, nor with side effects. Drugs other than risperidone were not associated with high prolactin levels. For patients on continuous monotherapy... (More)
Objective: To investigate prolactin levels and related side effects in 128 men and 90 women initially treated with risperidone. Method: Patients initially treated with risperidone were followed over 5 years, during which 45% were switched to other antipsychotic drugs. Results: Initially, prolactin levels were fivefold the norm in women, and threefold in men. Diagnosis did not affect the prolactin level if adjustment for sex, current age, and age at onset of psychosis was applied. Prolactin levels did not correlate significantly neither with any Positive and Negative Symptom Scale item or subscale, nor with side effects. Drugs other than risperidone were not associated with high prolactin levels. For patients on continuous monotherapy risperidone treatment, there was a marked linear reduction of prolactin level over all 5 years. Conclusion: Risperidone induces a higher prolactin elevation than other atypical antipsychotics, but the effect adapts over time. Prolactin was not associated with expected side effects (e.g. sexual, mental, or weight gain). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
psychosis, prolactin, side effects, risperidone
in
Acta Psychiatrica Scandinavica
volume
115
issue
4
pages
268 - 276
publisher
Wiley-Blackwell
external identifiers
  • wos:000244877800003
  • scopus:33947287461
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2006.00897.x
language
English
LU publication?
yes
id
3ba016f5-32aa-47e7-bfab-6df2b60e93e4 (old id 620322)
date added to LUP
2007-11-22 17:12:07
date last changed
2017-08-09 14:53:57
@article{3ba016f5-32aa-47e7-bfab-6df2b60e93e4,
  abstract     = {Objective: To investigate prolactin levels and related side effects in 128 men and 90 women initially treated with risperidone. Method: Patients initially treated with risperidone were followed over 5 years, during which 45% were switched to other antipsychotic drugs. Results: Initially, prolactin levels were fivefold the norm in women, and threefold in men. Diagnosis did not affect the prolactin level if adjustment for sex, current age, and age at onset of psychosis was applied. Prolactin levels did not correlate significantly neither with any Positive and Negative Symptom Scale item or subscale, nor with side effects. Drugs other than risperidone were not associated with high prolactin levels. For patients on continuous monotherapy risperidone treatment, there was a marked linear reduction of prolactin level over all 5 years. Conclusion: Risperidone induces a higher prolactin elevation than other atypical antipsychotics, but the effect adapts over time. Prolactin was not associated with expected side effects (e.g. sexual, mental, or weight gain).},
  author       = {Eberhard, Jonas and Lindström, E and Holstad, M. and Levander, Sten},
  issn         = {1600-0447},
  keyword      = {psychosis,prolactin,side effects,risperidone},
  language     = {eng},
  number       = {4},
  pages        = {268--276},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Prolactin level during 5 years of risperidone treatment in patients with psychotic disorders.},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2006.00897.x},
  volume       = {115},
  year         = {2007},
}