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PROTEIN HC A low molecular weight plasma protein

Tejler, Lars (1978)
Abstract
Protein HC or alpha-1-microglobulin is a human glycoproteinof low molecular weight (25-30,000) present in plasma, urine and cerebrospinal fluid. It also occurs in association with the surface of various human cell types.
The protein, containing only one polypeptide chain, is heterogeneous in charge, even when desialylated, has a marked tendency to form complexes with other plasma proteins, e.g., IgA and albumin, and is strongly associated with an unidentified chromophore material(s) that gives the purified protein a light brown color. Its amino-terminal amino acid sequence is:
Gly-Pro-Val-Pro-Arg-Pro-Pro-Asp-Asn-Ile-Gln-Val-Gln-Glu-Asn-Phe-Phe-Ile-Ser-Arg-Ile-Tyr-Gly-Arg-Trp-Tyr-Asn-Leu-Ile-Ala

The kidney is probablythe... (More)
Protein HC or alpha-1-microglobulin is a human glycoproteinof low molecular weight (25-30,000) present in plasma, urine and cerebrospinal fluid. It also occurs in association with the surface of various human cell types.
The protein, containing only one polypeptide chain, is heterogeneous in charge, even when desialylated, has a marked tendency to form complexes with other plasma proteins, e.g., IgA and albumin, and is strongly associated with an unidentified chromophore material(s) that gives the purified protein a light brown color. Its amino-terminal amino acid sequence is:
Gly-Pro-Val-Pro-Arg-Pro-Pro-Asp-Asn-Ile-Gln-Val-Gln-Glu-Asn-Phe-Phe-Ile-Ser-Arg-Ile-Tyr-Gly-Arg-Trp-Tyr-Asn-Leu-Ile-Ala

The kidney is probablythe main site of its catabolism and the liver producesappreciable amounts of the protein.

The mean adult normal plasma concentration has been estimated to be 32-98 mg/L. The protein is not an acute phase reactant. The plasma level of the protein is higher in males than in females and increases during pregnancy. Young fetuses have serum levels exceeding those in adults, but levels in cord blood are lower than in maternal plasma. (Less)
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author
supervisor
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type
Thesis
publication status
published
subject
keywords
Proteins: analysis, Plasma proteins, urine analysis
pages
28 pages
language
English
LU publication?
no
id
620efae5-7356-4da6-b5b0-4d4a332ce282
date added to LUP
2022-03-12 15:23:35
date last changed
2022-03-15 12:29:37
@phdthesis{620efae5-7356-4da6-b5b0-4d4a332ce282,
  abstract     = {{Protein HC or alpha-1-microglobulin is a human glycoproteinof low molecular weight (25-30,000) present in plasma, urine and cerebrospinal fluid. It also occurs in association with the surface of various human cell types.<br/>The protein, containing only one polypeptide chain, is heterogeneous in charge, even when desialylated, has a marked tendency to form complexes with other plasma proteins, e.g., IgA and albumin, and is strongly associated with an unidentified chromophore material(s) that gives the purified protein a light brown color. Its amino-terminal amino acid sequence is:<br/>Gly-Pro-Val-Pro-Arg-Pro-Pro-Asp-Asn-Ile-Gln-Val-Gln-Glu-Asn-Phe-Phe-Ile-Ser-Arg-Ile-Tyr-Gly-Arg-Trp-Tyr-Asn-Leu-Ile-Ala<br/><br/>The kidney is probablythe main site of its catabolism and the liver producesappreciable amounts of the protein.<br/><br/>The mean adult normal plasma concentration has been estimated to be 32-98 mg/L. The protein is not an acute phase reactant. The plasma level of the protein is higher in males than in females and increases during pregnancy. Young fetuses have serum levels exceeding those in adults, but levels in cord blood are lower than in maternal plasma.}},
  author       = {{Tejler, Lars}},
  keywords     = {{Proteins: analysis; Plasma proteins; urine analysis}},
  language     = {{eng}},
  month        = {{05}},
  title        = {{PROTEIN HC A low molecular weight plasma protein}},
  year         = {{1978}},
}