Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins.
(2004) In Arteriosclerosis, Thrombosis and Vascular Biology 24(2). p.337-341- Abstract
- Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.
Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future... (More) - Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.
Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and >=3 ISPs, respectively, in the top quartile (trend: P<0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004).
Conclusion— The incidence of fatal or repaired AAA is associated with the ISP levels. In this population-based study, elevated ISPs could be observed many years before the clinical manifestation of disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/119542
- author
- Engström, Gunnar LU ; Borner, Gabriel ; Lindblad, Bengt LU ; Janzon, Lars LU and Lindgärde, Folke LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- epidemiology, inflammation, aneurysm
- in
- Arteriosclerosis, Thrombosis and Vascular Biology
- volume
- 24
- issue
- 2
- pages
- 337 - 341
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000188777400020
- pmid:14684427
- scopus:1042279521
- ISSN
- 1524-4636
- DOI
- 10.1161/01.ATV.0000113292.00300.55
- language
- English
- LU publication?
- yes
- id
- 622b26b9-10be-4ae6-8bfe-b7b9bef5ae79 (old id 119542)
- date added to LUP
- 2016-04-01 12:36:18
- date last changed
- 2022-01-27 07:22:53
@article{622b26b9-10be-4ae6-8bfe-b7b9bef5ae79, abstract = {{Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown.<br/><br> <br/><br> Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mean age 46.8±3.7 years. After a mean time of 19 years, 63 men had a fatal or surgically/endovascularly repaired AAA. Risk of treatment or death from future AAA was studied in relation to the ISPs. The risk of future AAA increased significantly with the number of elevated ISPs (ie, in the top quartile). The proportions with future AAA were 0.4%, 1.0%, 1.3%, and 2.3% for men with none, one, two, and >=3 ISPs, respectively, in the top quartile (trend: P<0.0001). The corresponding odds ratios were 1.00 (reference), 1.9 (95% CI: 0.8 to 4.5), 2.2 (0.9 to 5.5), and 3.2 (1.4 to 7.2), respectively, adjusted for age, screening year, smoking, cholesterol, triglycerides, systolic blood pressure and physical inactivity (trend: P=0.004).<br/><br> <br/><br> Conclusion— The incidence of fatal or repaired AAA is associated with the ISP levels. In this population-based study, elevated ISPs could be observed many years before the clinical manifestation of disease.}}, author = {{Engström, Gunnar and Borner, Gabriel and Lindblad, Bengt and Janzon, Lars and Lindgärde, Folke}}, issn = {{1524-4636}}, keywords = {{epidemiology; inflammation; aneurysm}}, language = {{eng}}, number = {{2}}, pages = {{337--341}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Arteriosclerosis, Thrombosis and Vascular Biology}}, title = {{Incidence of Fatal or Repaired Abdominal Aortic Aneurysm in Relation to Inflammation-Sensitive Plasma Proteins.}}, url = {{http://dx.doi.org/10.1161/01.ATV.0000113292.00300.55}}, doi = {{10.1161/01.ATV.0000113292.00300.55}}, volume = {{24}}, year = {{2004}}, }