Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis - treatment effects of neuromuscular exercise and total joint replacement
Kosek, E. ; Roos, E. M. ; Ageberg, Eva LU
and Nilsdotter, A.
(2013)
In Osteoarthritis and Cartilage
21(9).
p.1299-1307
- Abstract
- Objective: To assess exercise induced analgesia (EIA) and pain sensitivity in hip and knee osteoarthritis (OA) and to study the effects of neuromuscular exercise and surgery on these parameters. Design: The dataset consisted of knee (n = 66) and hip (n = 47) OA patients assigned for total joint replacement at Lund University Hospital undergoing pre-operative neuromuscular exercise and 43 matched controls. Sensitivity to pressure pain was assessed by pressure algometry at 10 sites. Subjects were then instructed to perform a standardized static knee extension. Pressure pain thresholds (PPTs) were assessed at the contracting quadriceps muscle (Q) and at the resting deltoid muscle (D) before and during contraction. The relative increase in... (More)
- Objective: To assess exercise induced analgesia (EIA) and pain sensitivity in hip and knee osteoarthritis (OA) and to study the effects of neuromuscular exercise and surgery on these parameters. Design: The dataset consisted of knee (n = 66) and hip (n = 47) OA patients assigned for total joint replacement at Lund University Hospital undergoing pre-operative neuromuscular exercise and 43 matched controls. Sensitivity to pressure pain was assessed by pressure algometry at 10 sites. Subjects were then instructed to perform a standardized static knee extension. Pressure pain thresholds (PPTs) were assessed at the contracting quadriceps muscle (Q) and at the resting deltoid muscle (D) before and during contraction. The relative increase in PPTs during contraction was taken as a measure of localized (Q) or generalized (D) EIA. Patients were assessed at baseline, following on average 12 weeks of neuromuscular exercise and 3 months following surgery. Results: We found a normal function of EIA in OA patients at baseline. Previous studies have reported beneficial effects of physical exercise on pain modulation in healthy subjects. However, no treatment effects on EIA were seen in OA patients despite the increase in muscle strength following neuromuscular exercise and reduced pain following surgery. Compared to controls, OA patients had increased pain sensitivity and no beneficial effects on pain sensitivity were seen following treatment. Conclusions: To our knowledge, this is the first study of EIA in OA patients. Despite increased pain sensitivity, OA patients had a normal function of EIA. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172594
- author
- Kosek, E.
; Roos, E. M.
; Ageberg, Eva
LU
and Nilsdotter, A.
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Osteoarthritis, Exercise induced analgesia, Exercise, Hyperalgesia, Pressure pain thresholds, Pressure algometry
- in
- Osteoarthritis and Cartilage
- volume
- 21
- issue
- 9
- pages
- 1299 - 1307
- publisher
- Elsevier
- external identifiers
-
- wos:000324962200022
- scopus:84882671516
- pmid:23973144
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2013.06.019
- language
- English
- LU publication?
- yes
- id
- 6235db4b-c9a8-4256-88db-1399caca24bf (old id 4172594)
- date added to LUP
- 2016-04-01 10:25:10
- date last changed
- 2024-02-21 15:48:22
@article{6235db4b-c9a8-4256-88db-1399caca24bf,
abstract = {{Objective: To assess exercise induced analgesia (EIA) and pain sensitivity in hip and knee osteoarthritis (OA) and to study the effects of neuromuscular exercise and surgery on these parameters. Design: The dataset consisted of knee (n = 66) and hip (n = 47) OA patients assigned for total joint replacement at Lund University Hospital undergoing pre-operative neuromuscular exercise and 43 matched controls. Sensitivity to pressure pain was assessed by pressure algometry at 10 sites. Subjects were then instructed to perform a standardized static knee extension. Pressure pain thresholds (PPTs) were assessed at the contracting quadriceps muscle (Q) and at the resting deltoid muscle (D) before and during contraction. The relative increase in PPTs during contraction was taken as a measure of localized (Q) or generalized (D) EIA. Patients were assessed at baseline, following on average 12 weeks of neuromuscular exercise and 3 months following surgery. Results: We found a normal function of EIA in OA patients at baseline. Previous studies have reported beneficial effects of physical exercise on pain modulation in healthy subjects. However, no treatment effects on EIA were seen in OA patients despite the increase in muscle strength following neuromuscular exercise and reduced pain following surgery. Compared to controls, OA patients had increased pain sensitivity and no beneficial effects on pain sensitivity were seen following treatment. Conclusions: To our knowledge, this is the first study of EIA in OA patients. Despite increased pain sensitivity, OA patients had a normal function of EIA. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.}},
author = {{Kosek, E. and Roos, E. M. and Ageberg, Eva and Nilsdotter, A.}},
issn = {{1063-4584}},
keywords = {{Osteoarthritis; Exercise induced analgesia; Exercise; Hyperalgesia; Pressure pain thresholds; Pressure algometry}},
language = {{eng}},
number = {{9}},
pages = {{1299--1307}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis - treatment effects of neuromuscular exercise and total joint replacement}},
url = {{http://dx.doi.org/10.1016/j.joca.2013.06.019}},
doi = {{10.1016/j.joca.2013.06.019}},
volume = {{21}},
year = {{2013}},
}