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Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.

Andersson, Elin LU ; Hebsgaard, Josephine LU ; Parmar, Malin LU ; Guillemot, F and Björklund, Anders LU (2006) In Development 133(3). p.507-516
Abstract
Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to... (More)
Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to specifically affect the generation of DA neurons, as the development of other types of neurons within the ventral midbrain is unaltered. Ngn2 is the first example of a gene expressed in progenitors in the ventricular zone of the mesDA neuron domain that is essential for proper mesDA neuron differentiation, and whose loss of function causes impaired mesDA neurogenesis without other major abnormalities in the ventral midbrain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Development
volume
133
issue
3
pages
507 - 516
publisher
Society for International Development
external identifiers
  • wos:000235910500012
  • pmid:16396906
  • scopus:33244474408
ISSN
1477-9129
DOI
10.1242/dev.02224
language
English
LU publication?
yes
id
624509c6-a469-4706-af4d-513c6e128426 (old id 150467)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16396906&dopt=Abstract
date added to LUP
2007-07-09 16:23:08
date last changed
2019-09-17 01:47:53
@article{624509c6-a469-4706-af4d-513c6e128426,
  abstract     = {Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to specifically affect the generation of DA neurons, as the development of other types of neurons within the ventral midbrain is unaltered. Ngn2 is the first example of a gene expressed in progenitors in the ventricular zone of the mesDA neuron domain that is essential for proper mesDA neuron differentiation, and whose loss of function causes impaired mesDA neurogenesis without other major abnormalities in the ventral midbrain.},
  author       = {Andersson, Elin and Hebsgaard, Josephine and Parmar, Malin and Guillemot, F and Björklund, Anders},
  issn         = {1477-9129},
  language     = {eng},
  number       = {3},
  pages        = {507--516},
  publisher    = {Society for International Development},
  series       = {Development},
  title        = {Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.},
  url          = {http://dx.doi.org/10.1242/dev.02224},
  volume       = {133},
  year         = {2006},
}