Apoptins: selective anticancer agents
(2014) In Trends in Molecular Medicine 20(9). p.519-528- Abstract
- •Apoptins are viral proteins that trigger cell death.
•Apoptins show cancer-selective toxicity.
•Potential delivery methods are being assayed for future apoptin clinical trials.
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to... (More) - •Apoptins are viral proteins that trigger cell death.
•Apoptins show cancer-selective toxicity.
•Potential delivery methods are being assayed for future apoptin clinical trials.
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/62c096f4-f1bd-494c-8888-f1d824958702
- author
- Rollano Penaloza, Oscar Miguel LU ; Lewandowska, Magdalena ; Stetefeld, Joerg ; Ossysek, Karolina ; Madej, Mariusz ; Bereta, Joanna ; Sobczak, Mateusz ; Shojaei, Shahla ; Ghavami, Saeid and Los, Marek
- publishing date
- 2014-08-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anticancer agents, anaphase-promoting complex, CDK2, protein kinase C, protein phosphatase 2A
- in
- Trends in Molecular Medicine
- volume
- 20
- issue
- 9
- pages
- 519 - 528
- publisher
- Elsevier
- external identifiers
-
- scopus:84931839372
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2014.07.003
- language
- English
- LU publication?
- no
- id
- 62c096f4-f1bd-494c-8888-f1d824958702
- date added to LUP
- 2016-10-13 09:47:17
- date last changed
- 2022-11-13 00:26:08
@article{62c096f4-f1bd-494c-8888-f1d824958702, abstract = {{•Apoptins are viral proteins that trigger cell death.<br/>•Apoptins show cancer-selective toxicity.<br/>•Potential delivery methods are being assayed for future apoptin clinical trials.<br/>Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.}}, author = {{Rollano Penaloza, Oscar Miguel and Lewandowska, Magdalena and Stetefeld, Joerg and Ossysek, Karolina and Madej, Mariusz and Bereta, Joanna and Sobczak, Mateusz and Shojaei, Shahla and Ghavami, Saeid and Los, Marek}}, issn = {{1471-4914}}, keywords = {{anticancer agents; anaphase-promoting complex; CDK2; protein kinase C; protein phosphatase 2A}}, language = {{eng}}, month = {{08}}, number = {{9}}, pages = {{519--528}}, publisher = {{Elsevier}}, series = {{Trends in Molecular Medicine}}, title = {{Apoptins: selective anticancer agents}}, url = {{http://dx.doi.org/10.1016/j.molmed.2014.07.003}}, doi = {{10.1016/j.molmed.2014.07.003}}, volume = {{20}}, year = {{2014}}, }