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Apoptins: selective anticancer agents

Rollano Penaloza, Oscar Miguel LU ; Lewandowska, Magdalena ; Stetefeld, Joerg; Ossysek, Karolina ; Madej, Mariusz ; Bereta, Joanna; Sobczak, Mateusz; Shojaei, Shahla; Ghavami, Saeid and Los, Marek (2014) In Trends in Molecular Medicine 20(9). p.519-528
Abstract
•Apoptins are viral proteins that trigger cell death.
•Apoptins show cancer-selective toxicity.
•Potential delivery methods are being assayed for future apoptin clinical trials.
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to... (More)
•Apoptins are viral proteins that trigger cell death.
•Apoptins show cancer-selective toxicity.
•Potential delivery methods are being assayed for future apoptin clinical trials.
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anticancer agents, anaphase-promoting complex, CDK2, protein kinase C, protein phosphatase 2A
in
Trends in Molecular Medicine
volume
20
issue
9
pages
519 - 528
publisher
Elsevier
external identifiers
  • scopus:84931839372
ISSN
1471-4914
DOI
10.1016/j.molmed.2014.07.003
language
English
LU publication?
no
id
62c096f4-f1bd-494c-8888-f1d824958702
date added to LUP
2016-10-13 09:47:17
date last changed
2017-11-19 04:33:53
@article{62c096f4-f1bd-494c-8888-f1d824958702,
  abstract     = {•Apoptins are viral proteins that trigger cell death.<br/>•Apoptins show cancer-selective toxicity.<br/>•Potential delivery methods are being assayed for future apoptin clinical trials.<br/>Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.},
  author       = {Rollano Penaloza, Oscar Miguel and Lewandowska, Magdalena  and Stetefeld, Joerg and Ossysek, Karolina  and Madej, Mariusz  and Bereta, Joanna and Sobczak, Mateusz and Shojaei, Shahla and Ghavami, Saeid and Los, Marek},
  issn         = {1471-4914},
  keyword      = {anticancer agents,anaphase-promoting complex,CDK2,protein kinase C,protein phosphatase 2A},
  language     = {eng},
  month        = {08},
  number       = {9},
  pages        = {519--528},
  publisher    = {Elsevier},
  series       = {Trends in Molecular Medicine},
  title        = {Apoptins: selective anticancer agents},
  url          = {http://dx.doi.org/10.1016/j.molmed.2014.07.003},
  volume       = {20},
  year         = {2014},
}