Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries
(2020) In Diabetes Care 43(10). p.2403-2410- Abstract
OBJECTIVE: The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent.
RESEARCH DESIGN AND METHODS: We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs)... (More)
OBJECTIVE: The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent.
RESEARCH DESIGN AND METHODS: We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and diabetes using multilevel mixed-effects logistic regression models. We estimated ORs for the pooled sample, major world regions, and individual countries, in addition to stratifying all analyses by sex. We examined heterogeneity by individual-level characteristics.
RESULTS: Our sample included 554,122 individuals across 25 population-based surveys. Average height was 161.7 cm (95% CI 161.2-162.3), and the crude prevalence of diabetes was 7.5% (95% CI 6.9-8.2). We found no relationship between adult height and diabetes across LMICs globally or in most world regions. When stratifying our sample by country and sex, we found an inverse association between adult height and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model specifications.
CONCLUSIONS: Adult height is not associated with diabetes across LMICs. Environmental factors in early life reflected in attained adult height likely differ from those predisposing individuals for diabetes.
(Less)
- author
- organization
- publishing date
- 2020-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 43
- issue
- 10
- pages
- 8 pages
- publisher
- American Diabetes Association
- external identifiers
-
- scopus:85091469743
- pmid:32764150
- pmid:32764150
- ISSN
- 1935-5548
- DOI
- 10.2337/dc20-0019
- language
- English
- LU publication?
- yes
- id
- 62d2ac7a-7994-4be6-b1ce-5980642db93c
- date added to LUP
- 2020-08-19 11:49:15
- date last changed
- 2024-06-26 22:00:02
@article{62d2ac7a-7994-4be6-b1ce-5980642db93c,
abstract = {{<p>OBJECTIVE: The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where such conditions are prominent.</p><p>RESEARCH DESIGN AND METHODS: We pooled individual-level data from nationally representative surveys in LMICs that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and diabetes using multilevel mixed-effects logistic regression models. We estimated ORs for the pooled sample, major world regions, and individual countries, in addition to stratifying all analyses by sex. We examined heterogeneity by individual-level characteristics.</p><p>RESULTS: Our sample included 554,122 individuals across 25 population-based surveys. Average height was 161.7 cm (95% CI 161.2-162.3), and the crude prevalence of diabetes was 7.5% (95% CI 6.9-8.2). We found no relationship between adult height and diabetes across LMICs globally or in most world regions. When stratifying our sample by country and sex, we found an inverse association between adult height and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model specifications.</p><p>CONCLUSIONS: Adult height is not associated with diabetes across LMICs. Environmental factors in early life reflected in attained adult height likely differ from those predisposing individuals for diabetes.</p>}},
author = {{Teufel, Felix and Geldsetzer, Pascal and Manne-Goehler, Jennifer and Karlsson, Omar and Koncz, Viola and Deckert, Andreas and Theilmann, Michaela and Marcus, Maja-Emilia and Ebert, Cara and Seiglie, Jacqueline A and Agoudavi, Kokou and Andall-Brereton, Glennis and Gathecha, Gladwell and Gurung, Mongal S and Guwatudde, David and Houehanou, Corine and Hwalla, Nahla and Kagaruki, Gibson B and Karki, Khem B and Labadarios, Demetre and Martins, Joao S and Msaidie, Mohamed and Norov, Bolormaa and Sibai, Abla M and Sturua, Lela and Tsabedze, Lindiwe and Wesseh, Chea S and Davies, Justine and Atun, Rifat and Vollmer, Sebastian and Subramanian, S V and Bärnighausen, Till and Jaacks, Lindsay M and De Neve, Jan-Walter}},
issn = {{1935-5548}},
language = {{eng}},
month = {{10}},
number = {{10}},
pages = {{2403--2410}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle-Income Countries}},
url = {{http://dx.doi.org/10.2337/dc20-0019}},
doi = {{10.2337/dc20-0019}},
volume = {{43}},
year = {{2020}},
}