Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes
Matti, Nathalie ; Javanshiri, Keivan LU
; Haglund, Mattias
LU
; Saenz-Sardá, Xavier
and Englund, Elisabet
LU
(2022)
In Journal of Alzheimer's Disease
89(2).
p.463-471
- Abstract
Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro-and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. Results: A total of 85 FTLD cases were... (More)
Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro-and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. Results: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro-and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. Conclusion: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging.
(Less)
- author
- Matti, Nathalie
; Javanshiri, Keivan
LU
; Haglund, Mattias
LU
; Saenz-Sardá, Xavier
and Englund, Elisabet
LU
- organization
- publishing date
- 2022-07-20
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Frontotemporal dementia, locus coeruleus, neuronal counts, tau, tauopathy, TDP-43
- in
- Journal of Alzheimer's Disease
- volume
- 89
- issue
- 2
- pages
- 9 pages
- publisher
- IOS Press
- external identifiers
-
- pmid:35871340
- scopus:85138454941
- ISSN
- 1387-2877
- DOI
- 10.3233/JAD-220276
- language
- English
- LU publication?
- yes
- id
- 62ecbdef-36c7-448e-b8ab-809c41705eee
- date added to LUP
- 2022-12-30 14:12:25
- date last changed
- 2024-10-14 20:18:41
@article{62ecbdef-36c7-448e-b8ab-809c41705eee,
abstract = {{<p>Background: There are few studies on the locus coeruleus (LC) in frontotemporal lobar degeneration (FTLD) and the potential differences in the LC related to the underlying proteinopathy. Objective: The aim of this study was to investigate the LC in FTLD subgroups. Methods: Neuropathological cases diagnosed with FTLD were included. The subgroups consisted of FTLD with tau, transactive response DNA-binding protein 43 (TDP) and fused in sarcoma (FUS). Micro-and macroscopical degeneration of the LC were assessed with respect to the number of neurons and the degree of depigmentation. A group of cognitively healthy subjects and a group with vascular cognitive impairment (VCI) served as comparison groups. Results: A total of 85 FTLD cases were included, of which 44 had FTLD-TDP, 38 had FTLD-tau, and three had FTLD-FUS. The groups were compared with 25 VCI cases and 41 cognitively healthy control cases (N = 151 for the entire study). All FTLD groups had a statistically higher microscopical degeneration of the LC compared to the controls, but the FTLD-tau group had greater micro-and macroscopical degeneration than the FTLD-TDP group. Age correlated positively with the LC score in the FTLD-tau group, but not in the FTLD-TDP group. Conclusion: A greater microscopical degeneration of the LC was observed in all FTLD cases compared to healthy controls and those with VCI. The LC degeneration was more severe in FTLD-tau than in FTLD-TDP. The macroscopically differential degeneration of the LC in FTLD subgroups may facilitate differential diagnostics, potentially with imaging.</p>}},
author = {{Matti, Nathalie and Javanshiri, Keivan and Haglund, Mattias and Saenz-Sardá, Xavier and Englund, Elisabet}},
issn = {{1387-2877}},
keywords = {{Frontotemporal dementia; locus coeruleus; neuronal counts; tau; tauopathy; TDP-43}},
language = {{eng}},
month = {{07}},
number = {{2}},
pages = {{463--471}},
publisher = {{IOS Press}},
series = {{Journal of Alzheimer's Disease}},
title = {{Locus Coeruleus Degeneration Differs Between Frontotemporal Lobar Degeneration Subtypes}},
url = {{http://dx.doi.org/10.3233/JAD-220276}},
doi = {{10.3233/JAD-220276}},
volume = {{89}},
year = {{2022}},
}