Mapping gene transcription and neurocognition across human neocortex
(2021) In Nature Human Behaviour 5(9). p.1240-1250- Abstract
Regulation of gene expression drives protein interactions that govern synaptic wiring and neuronal activity. The resulting coordinated activity among neuronal populations supports complex psychological processes, yet how gene expression shapes cognition and emotion remains unknown. Here, we directly bridge the microscale and macroscale by mapping gene expression patterns to functional activation patterns across the cortical sheet. Applying unsupervised learning to the Allen Human Brain Atlas and Neurosynth databases, we identify a ventromedial-dorsolateral gradient of gene assemblies that separate affective and perceptual domains. This topographic molecular-psychological signature reflects the hierarchical organization of the neocortex,... (More)
Regulation of gene expression drives protein interactions that govern synaptic wiring and neuronal activity. The resulting coordinated activity among neuronal populations supports complex psychological processes, yet how gene expression shapes cognition and emotion remains unknown. Here, we directly bridge the microscale and macroscale by mapping gene expression patterns to functional activation patterns across the cortical sheet. Applying unsupervised learning to the Allen Human Brain Atlas and Neurosynth databases, we identify a ventromedial-dorsolateral gradient of gene assemblies that separate affective and perceptual domains. This topographic molecular-psychological signature reflects the hierarchical organization of the neocortex, including systematic variations in cell type, myeloarchitecture, laminar differentiation and intrinsic network affiliation. In addition, this molecular-psychological signature strengthens over neurodevelopment and can be replicated in two independent repositories. Collectively, our results reveal spatially covarying transcriptomic and cognitive architectures, highlighting the influence that molecular mechanisms exert on psychological processes.
(Less)
- author
- Hansen, Justine Y ; Markello, Ross D ; Vogel, Jacob W LU ; Seidlitz, Jakob ; Bzdok, Danilo and Misic, Bratislav
- publishing date
- 2021-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain Mapping/methods, Cognition, Gene Expression/physiology, Gene Expression Profiling/methods, Humans, Image Processing, Computer-Assisted, Neocortex/metabolism
- in
- Nature Human Behaviour
- volume
- 5
- issue
- 9
- pages
- 1240 - 1250
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85103173628
- pmid:33767429
- ISSN
- 2397-3374
- DOI
- 10.1038/s41562-021-01082-z
- language
- English
- LU publication?
- no
- additional info
- © 2021. The Author(s), under exclusive licence to Springer Nature Limited.
- id
- 62ef685d-191a-4fda-bf66-0915def7d4b5
- date added to LUP
- 2024-02-28 20:01:41
- date last changed
- 2024-04-14 02:11:03
@article{62ef685d-191a-4fda-bf66-0915def7d4b5,
abstract = {{<p>Regulation of gene expression drives protein interactions that govern synaptic wiring and neuronal activity. The resulting coordinated activity among neuronal populations supports complex psychological processes, yet how gene expression shapes cognition and emotion remains unknown. Here, we directly bridge the microscale and macroscale by mapping gene expression patterns to functional activation patterns across the cortical sheet. Applying unsupervised learning to the Allen Human Brain Atlas and Neurosynth databases, we identify a ventromedial-dorsolateral gradient of gene assemblies that separate affective and perceptual domains. This topographic molecular-psychological signature reflects the hierarchical organization of the neocortex, including systematic variations in cell type, myeloarchitecture, laminar differentiation and intrinsic network affiliation. In addition, this molecular-psychological signature strengthens over neurodevelopment and can be replicated in two independent repositories. Collectively, our results reveal spatially covarying transcriptomic and cognitive architectures, highlighting the influence that molecular mechanisms exert on psychological processes.</p>}},
author = {{Hansen, Justine Y and Markello, Ross D and Vogel, Jacob W and Seidlitz, Jakob and Bzdok, Danilo and Misic, Bratislav}},
issn = {{2397-3374}},
keywords = {{Brain Mapping/methods; Cognition; Gene Expression/physiology; Gene Expression Profiling/methods; Humans; Image Processing, Computer-Assisted; Neocortex/metabolism}},
language = {{eng}},
number = {{9}},
pages = {{1240--1250}},
publisher = {{Nature Publishing Group}},
series = {{Nature Human Behaviour}},
title = {{Mapping gene transcription and neurocognition across human neocortex}},
url = {{http://dx.doi.org/10.1038/s41562-021-01082-z}},
doi = {{10.1038/s41562-021-01082-z}},
volume = {{5}},
year = {{2021}},
}