Tobacco smoke exposure in early life and adolescence in relation to lung function
(2018) In The European respiratory journal 51(6).- Abstract
Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced... (More)
Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of -1.1% (95% CI -2.0 to -0.2%). IOS demonstrated greater resistance at 5-20 Hz (R5-20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of -0.9% (95% CI -1.8 to -0.1%) and increased resistance of 6.5 Pa·L-1·s (95% CI 0.7 to 12.2 Pa·L-1·s) in R5-20 Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL-1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.
(Less)
- author
- Thacher, Jesse D LU ; Schultz, Erica S ; Hallberg, Jenny ; Hellberg, Ulrika ; Kull, Inger ; Thunqvist, Per ; Pershagen, Göran ; Gustafsson, Per M ; Melén, Erik and Bergström, Anna
- publishing date
- 2018-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Biomarkers/analysis, Cotinine/analysis, Female, Forced Expiratory Volume, Humans, Linear Models, Lung/physiopathology, Male, Pregnancy, Prenatal Exposure Delayed Effects/epidemiology, Saliva/chemistry, Sex Distribution, Smoking/epidemiology, Spirometry, Tobacco Smoke Pollution/adverse effects, Vital Capacity
- in
- The European respiratory journal
- volume
- 51
- issue
- 6
- article number
- 1702111
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:85048248461
- pmid:29748304
- ISSN
- 1399-3003
- DOI
- 10.1183/13993003.02111-2017
- language
- English
- LU publication?
- no
- additional info
- Copyright ©ERS 2018.
- id
- 62fcbfa0-6da0-4fb2-9806-43332f7f0c55
- date added to LUP
- 2023-05-08 10:56:56
- date last changed
- 2024-04-05 19:15:15
@article{62fcbfa0-6da0-4fb2-9806-43332f7f0c55,
abstract = {{<p>Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of -1.1% (95% CI -2.0 to -0.2%). IOS demonstrated greater resistance at 5-20 Hz (R5-20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of -0.9% (95% CI -1.8 to -0.1%) and increased resistance of 6.5 Pa·L-1·s (95% CI 0.7 to 12.2 Pa·L-1·s) in R5-20 Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL-1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.</p>}},
author = {{Thacher, Jesse D and Schultz, Erica S and Hallberg, Jenny and Hellberg, Ulrika and Kull, Inger and Thunqvist, Per and Pershagen, Göran and Gustafsson, Per M and Melén, Erik and Bergström, Anna}},
issn = {{1399-3003}},
keywords = {{Adolescent; Biomarkers/analysis; Cotinine/analysis; Female; Forced Expiratory Volume; Humans; Linear Models; Lung/physiopathology; Male; Pregnancy; Prenatal Exposure Delayed Effects/epidemiology; Saliva/chemistry; Sex Distribution; Smoking/epidemiology; Spirometry; Tobacco Smoke Pollution/adverse effects; Vital Capacity}},
language = {{eng}},
number = {{6}},
publisher = {{European Respiratory Society}},
series = {{The European respiratory journal}},
title = {{Tobacco smoke exposure in early life and adolescence in relation to lung function}},
url = {{http://dx.doi.org/10.1183/13993003.02111-2017}},
doi = {{10.1183/13993003.02111-2017}},
volume = {{51}},
year = {{2018}},
}