Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine
Clementson, Sebastian LU
; Jessing, Mikkel
; Pedersen, Henrik
; Vital, Paulo
and Kristensen, Jesper L.
(2019)
In Journal of the American Chemical Society
141(22).
p.8783-8786
- Abstract
- Erythrina alkaloids represent a rich source of complex polycyclic,
bioactive natural products. In addition to their sedative and
hypotensive effect, their curare-like activity and structural framework
have made them attractive targets for synthetic and medicinal chemists.
(+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine
acetylcholine receptor antagonist (nAChR) of the Erythrina family, is
synthesized for the first time in 13 steps from commercially available
material.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/62fe29f0-181c-448b-8ad4-7a3ea0dc097d
- author
- Clementson, Sebastian
LU
; Jessing, Mikkel
; Pedersen, Henrik
; Vital, Paulo
and Kristensen, Jesper L.
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- in
- Journal of the American Chemical Society
- volume
- 141
- issue
- 22
- pages
- 4 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85066496111
- ISSN
- 1520-5126
- DOI
- 10.1021/jacs.9b04626
- language
- English
- LU publication?
- no
- additional info
- PMID: 31122014
- id
- 62fe29f0-181c-448b-8ad4-7a3ea0dc097d
- date added to LUP
- 2025-08-06 19:38:04
- date last changed
- 2025-08-28 13:02:10
@article{62fe29f0-181c-448b-8ad4-7a3ea0dc097d,
abstract = {{Erythrina alkaloids represent a rich source of complex polycyclic, <br>
bioactive natural products. In addition to their sedative and <br>
hypotensive effect, their curare-like activity and structural framework <br>
have made them attractive targets for synthetic and medicinal chemists. <br>
(+)-Dihydro-β-erythroidine (DHβE), the most potent nicotine <br>
acetylcholine receptor antagonist (nAChR) of the Erythrina family, is <br>
synthesized for the first time in 13 steps from commercially available <br>
material.}},
author = {{Clementson, Sebastian and Jessing, Mikkel and Pedersen, Henrik and Vital, Paulo and Kristensen, Jesper L.}},
issn = {{1520-5126}},
language = {{eng}},
number = {{22}},
pages = {{8783--8786}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of the American Chemical Society}},
title = {{Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine}},
url = {{http://dx.doi.org/10.1021/jacs.9b04626}},
doi = {{10.1021/jacs.9b04626}},
volume = {{141}},
year = {{2019}},
}