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The ELISA-Measured Increase in Cerebrospinal Fluid Tau that Discriminates Alzheimer's Disease from other Neurodegenerative Disorders is not Attributable to Differential Recognition of Tau Assembly Forms

O'Dowd, S. T. ; Ardah, M. T. ; Johansson, Per LU ; Lomakin, A. ; Benedek, G. B. ; Roberts, K. A. ; Cummins, G. ; El Agnaf, O. M. ; Svensson, J. and Zetterberg, H. , et al. (2013) In Journal of Alzheimer's Disease 33(4). p.923-928
Abstract
Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little is known about their ability to detect different aggregation states of tau. We demonstrate that the leading commercial enzyme-linked immunosorbent assay reliably detects aggregated and monomeric tau and evinces good recovery of both species when added into cerebrospinal fluid. Hence, the disparity between total-tau levels encountered in Alzheimer's disease and other neurodegenerative conditions is not due to differential recognition of tau assembly forms or the extent of degeneration.
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
OLIGOMERS, PROTEIN, DEMENTIA, CSF BIOMARKERS, RESEARCH CRITERIA, CLINICAL-DIAGNOSIS, PARKINSONS-DISEASE, CORTICOBASAL DEGENERATION, FRONTOTEMPORAL LOBAR DEGENERATION, PROGRESSIVE SUPRANUCLEAR PALSY
in
Journal of Alzheimer's Disease
volume
33
issue
4
pages
923 - 928
publisher
IOS Press
external identifiers
  • scopus:84873645714
  • pmid:23034520
ISSN
1387-2877
DOI
10.3233/JAD-2012-121393
project
Endocrine and diagnostic aspects of cognitive impairment
language
English
LU publication?
no
id
630d9504-51b6-48c8-9d43-ffa65f8d7357 (old id 8511178)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23034520
date added to LUP
2016-04-04 07:50:34
date last changed
2022-04-07 23:13:19
@article{630d9504-51b6-48c8-9d43-ffa65f8d7357,
  abstract     = {{Elevated cerebrospinal fluid concentrations of tau discriminate Alzheimer's disease from other neurodegenerative conditions. The reasons for this are unclear. While commercial assay kits are widely used to determine total-tau concentrations, little is known about their ability to detect different aggregation states of tau. We demonstrate that the leading commercial enzyme-linked immunosorbent assay reliably detects aggregated and monomeric tau and evinces good recovery of both species when added into cerebrospinal fluid. Hence, the disparity between total-tau levels encountered in Alzheimer's disease and other neurodegenerative conditions is not due to differential recognition of tau assembly forms or the extent of degeneration.}},
  author       = {{O'Dowd, S. T. and Ardah, M. T. and Johansson, Per and Lomakin, A. and Benedek, G. B. and Roberts, K. A. and Cummins, G. and El Agnaf, O. M. and Svensson, J. and Zetterberg, H. and Lynch, T. and Walsh, D. M.}},
  issn         = {{1387-2877}},
  keywords     = {{OLIGOMERS; PROTEIN; DEMENTIA; CSF BIOMARKERS; RESEARCH CRITERIA; CLINICAL-DIAGNOSIS; PARKINSONS-DISEASE; CORTICOBASAL DEGENERATION; FRONTOTEMPORAL LOBAR DEGENERATION; PROGRESSIVE SUPRANUCLEAR PALSY}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{923--928}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{The ELISA-Measured Increase in Cerebrospinal Fluid Tau that Discriminates Alzheimer's Disease from other Neurodegenerative Disorders is not Attributable to Differential Recognition of Tau Assembly Forms}},
  url          = {{http://dx.doi.org/10.3233/JAD-2012-121393}},
  doi          = {{10.3233/JAD-2012-121393}},
  volume       = {{33}},
  year         = {{2013}},
}