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Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion

Larsson, J ; Hillarp, A LU ; Olafsdottir, E and Bauer, B LU (1999) In Acta Ophthalmologica Scandinavica 77(6). p.634-637
Abstract

BACKGROUND: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion.

METHODS: 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants.

RESULTS:... (More)

BACKGROUND: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion.

METHODS: 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants.

RESULTS: Anticoagulant protein deficiencies were found in 4 patients (11%) and activated protein C resistance in 7 patients (19%). Anticardiolipin or lupus anticoagulants were not found in the patients.

CONCLUSION: Activated protein C resistance and anticoagulant protein deficiencies seem to be important factors to the etiology to central retinal vein occlusion in young patients.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Activated Protein C Resistance/blood, Adult, Antithrombin III Deficiency/metabolism, Blood Coagulation Factor Inhibitors/blood, Calmodulin-Binding Proteins/blood, DNA/analysis, Factor V/genetics, Female, Glycoproteins/blood, Humans, Male, Middle Aged, Plasminogen/deficiency, Point Mutation, Polymerase Chain Reaction, Prevalence, Protein S Deficiency/metabolism, Retinal Vein Occlusion/blood, Risk Factors, beta 2-Glycoprotein I
in
Acta Ophthalmologica Scandinavica
volume
77
issue
6
pages
4 pages
publisher
Wiley
external identifiers
  • pmid:10634554
  • scopus:0033429661
ISSN
1395-3907
DOI
10.1034/j.1600-0420.1999.770606.x
language
English
LU publication?
no
id
6324c2ce-93ff-4fea-996c-72cce591156e
date added to LUP
2022-08-29 10:24:59
date last changed
2024-01-03 16:15:37
@article{6324c2ce-93ff-4fea-996c-72cce591156e,
  abstract     = {{<p>BACKGROUND: Central retinal vein occlusion is a disease that is most common in old people, and often associated with atherosclerosis, hypertension, diabetes or glaucoma. Since these diseases are much less evident in young people, we wanted to investigate the prevalence of disorders in the most common anticoagulant proteins in a group of young patients with central retinal vein occlusion.</p><p>METHODS: 37 consecutive patients younger than 50 years and with a history of central retinal vein occlusion, were analysed for deficiencies of natural inhibitors of coagulation (protein C, S, and antithrombin III), plasminogen, resistance to activated protein C, and the presence of anticardiolipin or lupus anticoagulants.</p><p>RESULTS: Anticoagulant protein deficiencies were found in 4 patients (11%) and activated protein C resistance in 7 patients (19%). Anticardiolipin or lupus anticoagulants were not found in the patients.</p><p>CONCLUSION: Activated protein C resistance and anticoagulant protein deficiencies seem to be important factors to the etiology to central retinal vein occlusion in young patients.</p>}},
  author       = {{Larsson, J and Hillarp, A and Olafsdottir, E and Bauer, B}},
  issn         = {{1395-3907}},
  keywords     = {{Activated Protein C Resistance/blood; Adult; Antithrombin III Deficiency/metabolism; Blood Coagulation Factor Inhibitors/blood; Calmodulin-Binding Proteins/blood; DNA/analysis; Factor V/genetics; Female; Glycoproteins/blood; Humans; Male; Middle Aged; Plasminogen/deficiency; Point Mutation; Polymerase Chain Reaction; Prevalence; Protein S Deficiency/metabolism; Retinal Vein Occlusion/blood; Risk Factors; beta 2-Glycoprotein I}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{634--637}},
  publisher    = {{Wiley}},
  series       = {{Acta Ophthalmologica Scandinavica}},
  title        = {{Activated protein C resistance and anticoagulant proteins in young adults with central retinal vein occlusion}},
  url          = {{http://dx.doi.org/10.1034/j.1600-0420.1999.770606.x}},
  doi          = {{10.1034/j.1600-0420.1999.770606.x}},
  volume       = {{77}},
  year         = {{1999}},
}