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The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern

Zhong, Wen ; Danielsson, Hanna ; Brusselaers, Nele ; Wackernagel, Dirk ; Sjöbom, Ulrika ; Sävman, Karin ; Hansen Pupp, Ingrid LU orcid ; Ley, David LU ; Nilsson, Anders K and Fagerberg, Linn , et al. (2023) In Communications medicine 3(1).
Abstract

BACKGROUND: Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders.

METHODS: We have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples,... (More)

BACKGROUND: Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders.

METHODS: We have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples, collected longitudinally at nine time points from birth to full-term from 182 extremely preterm infants.

RESULTS: The protein analysis reveals evident predestined serum evolution patterns common for all included infants. The majority of the variations in blood protein expression are associated with the postnatal age of the preterm infants rather than any other factors. There is a uniform protein pattern on postnatal day 1 and after 30 weeks postmenstrual age (PMA), independent of gestational age (GA). However, during the first month of life, GA had a significant impact on protein variability.

CONCLUSIONS: The unified pattern of protein development for all included infants suggests an age-dependent stereotypic development of blood proteins after birth. This knowledge should be considered in neonatal settings and might alter the clinical approach within neonatology, where PMA is today the most dominant age variable.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Communications medicine
volume
3
issue
1
article number
107
publisher
Nature Publishing Group
external identifiers
  • pmid:37532738
ISSN
2730-664X
DOI
10.1038/s43856-023-00338-1
language
English
LU publication?
yes
additional info
© 2023. The Author(s).
id
63280460-8603-420d-bf95-9cbd0caa1e31
date added to LUP
2023-10-10 15:01:00
date last changed
2023-10-14 02:47:17
@article{63280460-8603-420d-bf95-9cbd0caa1e31,
  abstract     = {{<p>BACKGROUND: Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders.</p><p>METHODS: We have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples, collected longitudinally at nine time points from birth to full-term from 182 extremely preterm infants.</p><p>RESULTS: The protein analysis reveals evident predestined serum evolution patterns common for all included infants. The majority of the variations in blood protein expression are associated with the postnatal age of the preterm infants rather than any other factors. There is a uniform protein pattern on postnatal day 1 and after 30 weeks postmenstrual age (PMA), independent of gestational age (GA). However, during the first month of life, GA had a significant impact on protein variability.</p><p>CONCLUSIONS: The unified pattern of protein development for all included infants suggests an age-dependent stereotypic development of blood proteins after birth. This knowledge should be considered in neonatal settings and might alter the clinical approach within neonatology, where PMA is today the most dominant age variable.</p>}},
  author       = {{Zhong, Wen and Danielsson, Hanna and Brusselaers, Nele and Wackernagel, Dirk and Sjöbom, Ulrika and Sävman, Karin and Hansen Pupp, Ingrid and Ley, David and Nilsson, Anders K and Fagerberg, Linn and Uhlén, Mathias and Hellström, Ann}},
  issn         = {{2730-664X}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Communications medicine}},
  title        = {{The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern}},
  url          = {{http://dx.doi.org/10.1038/s43856-023-00338-1}},
  doi          = {{10.1038/s43856-023-00338-1}},
  volume       = {{3}},
  year         = {{2023}},
}