Widespread non-joint pain in early rheumatoid arthritis
(2021) In Scandinavian Journal of Rheumatology 50(4). p.271-279- Abstract
Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA), the associated health-related quality of life (HRQoL), and clinical and demographic risk factors for WNP. Method: Incident cases with RA, from the Swedish population-based study Epidemiological Investigation of Rheumatoid Arthritis (EIRA), with a follow-up of at least 3 years, constituted the study population. WNP was defined as pain outside the joints in all four body quadrants and was assessed at the 3 year follow-up. Patients who reported WNP were compared to patients without WNP regarding HRQoL, measured by the Short Form-36, at 3 years, and clinical and demographic... (More)
Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA), the associated health-related quality of life (HRQoL), and clinical and demographic risk factors for WNP. Method: Incident cases with RA, from the Swedish population-based study Epidemiological Investigation of Rheumatoid Arthritis (EIRA), with a follow-up of at least 3 years, constituted the study population. WNP was defined as pain outside the joints in all four body quadrants and was assessed at the 3 year follow-up. Patients who reported WNP were compared to patients without WNP regarding HRQoL, measured by the Short Form-36, at 3 years, and clinical and demographic characteristics at the time of RA diagnosis. Results: A total of 749 patients constituted the study sample, of whom 25 were excluded after reporting already having severe pain before RA diagnosis. At the 3 year follow-up, 8% of the patients reported having WNP as well as statistically significant worse HRQoL. At the time of RA diagnosis, the patients with WNP had worse pain and pain-related features, while no difference was seen in the inflammatory parameters. Conclusion: WNP occurs in a substantial subset of patients with RA, also early in the course of the disease, and the HRQoL for these patients is significantly reduced. Patients who develop WNP at 3 years are already distinguishable at the time of diagnosis by displaying more pronounced pain ratings together with an average level of inflammatory disease activity.
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- author
- Schelin, M. E.C. LU ; Westerlind, H. ; Lindqvist, J. ; Englid, E. ; Israelsson, L. ; Skillgate, E. ; Klareskog, L. ; Alfredsson, L. and Lampa, J.
- organization
- publishing date
- 2021-02-25
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Rheumatology
- volume
- 50
- issue
- 4
- pages
- 9 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85101656255
- pmid:33629632
- ISSN
- 0300-9742
- DOI
- 10.1080/03009742.2020.1846778
- language
- English
- LU publication?
- yes
- id
- 636f9de6-98d5-4018-aa5d-6d96078131fd
- date added to LUP
- 2021-03-16 08:05:49
- date last changed
- 2024-09-19 18:06:16
@article{636f9de6-98d5-4018-aa5d-6d96078131fd, abstract = {{<p>Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA), the associated health-related quality of life (HRQoL), and clinical and demographic risk factors for WNP. Method: Incident cases with RA, from the Swedish population-based study Epidemiological Investigation of Rheumatoid Arthritis (EIRA), with a follow-up of at least 3 years, constituted the study population. WNP was defined as pain outside the joints in all four body quadrants and was assessed at the 3 year follow-up. Patients who reported WNP were compared to patients without WNP regarding HRQoL, measured by the Short Form-36, at 3 years, and clinical and demographic characteristics at the time of RA diagnosis. Results: A total of 749 patients constituted the study sample, of whom 25 were excluded after reporting already having severe pain before RA diagnosis. At the 3 year follow-up, 8% of the patients reported having WNP as well as statistically significant worse HRQoL. At the time of RA diagnosis, the patients with WNP had worse pain and pain-related features, while no difference was seen in the inflammatory parameters. Conclusion: WNP occurs in a substantial subset of patients with RA, also early in the course of the disease, and the HRQoL for these patients is significantly reduced. Patients who develop WNP at 3 years are already distinguishable at the time of diagnosis by displaying more pronounced pain ratings together with an average level of inflammatory disease activity.</p>}}, author = {{Schelin, M. E.C. and Westerlind, H. and Lindqvist, J. and Englid, E. and Israelsson, L. and Skillgate, E. and Klareskog, L. and Alfredsson, L. and Lampa, J.}}, issn = {{0300-9742}}, language = {{eng}}, month = {{02}}, number = {{4}}, pages = {{271--279}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Rheumatology}}, title = {{Widespread non-joint pain in early rheumatoid arthritis}}, url = {{http://dx.doi.org/10.1080/03009742.2020.1846778}}, doi = {{10.1080/03009742.2020.1846778}}, volume = {{50}}, year = {{2021}}, }