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Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer

Miyamoto, Emiri ; Yoshihara, Masato ; Iyoshi, Shohei ; Mogi, Kazumasa ; Uno, Kaname LU orcid ; Fujimoto, Hiroki ; Koya, Yoshihiro ; Kitami, Kazuhisa ; Yoshida, Kosuke and Tamauchi, Satoshi , et al. (2025) In Scientific Reports 15(1).
Abstract

The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis,... (More)

The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis, and neutrophil indicators from blood tests. Survival analysis showed that neutrophil infiltration in the primary tumor had no impact on prognosis, whereas high neutrophil infiltration in the disseminated tumor significantly shortened progression-free survival and overall survival. No correlation was found between neutrophil infiltration and the number of peripheral blood neutrophils, the degree of neutropenia, area of vascular endothelial cells, and number of stromal cells. Neutrophil infiltration into disseminated lesions of the omentum has a significant impact on prognosis. The results of the present study may provide insights for refining clinical approaches.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Neutrophil, Ovarian carcinoma, Peritoneal metastasis, Prognosis
in
Scientific Reports
volume
15
issue
1
article number
23196
publisher
Nature Publishing Group
external identifiers
  • pmid:40603365
  • scopus:105010159696
ISSN
2045-2322
DOI
10.1038/s41598-025-05010-3
language
English
LU publication?
yes
id
6380ac2a-1543-4210-90e9-c98a27c3086c
date added to LUP
2025-10-29 09:43:16
date last changed
2025-10-30 03:29:39
@article{6380ac2a-1543-4210-90e9-c98a27c3086c,
  abstract     = {{<p>The impact on prognosis of neutrophil infiltration in the microenvironment of ovarian cancer remains to be elucidated. In this study, we analyzed the association between neutrophil infiltration in peritoneal metastasis and prognosis. Furthermore, we analyzed the correlation between neutrophil infiltration in peritoneal metastasis and the number of peripheral blood neutrophils, the degree of neutropenia, vascular endothelial area, and the number of stromal cells. Thirty-four specimens each of primary and metastatic advanced ovarian cancer with high-grade serous carcinoma histology were taken. Staining for MPO, CD31, and αSMA was performed on all specimens. We investigated the correlation among tissue neutrophil infiltration, prognosis, and neutrophil indicators from blood tests. Survival analysis showed that neutrophil infiltration in the primary tumor had no impact on prognosis, whereas high neutrophil infiltration in the disseminated tumor significantly shortened progression-free survival and overall survival. No correlation was found between neutrophil infiltration and the number of peripheral blood neutrophils, the degree of neutropenia, area of vascular endothelial cells, and number of stromal cells. Neutrophil infiltration into disseminated lesions of the omentum has a significant impact on prognosis. The results of the present study may provide insights for refining clinical approaches.</p>}},
  author       = {{Miyamoto, Emiri and Yoshihara, Masato and Iyoshi, Shohei and Mogi, Kazumasa and Uno, Kaname and Fujimoto, Hiroki and Koya, Yoshihiro and Kitami, Kazuhisa and Yoshida, Kosuke and Tamauchi, Satoshi and Yokoi, Akira and Yoshikawa, Nobuhisa and Niimi, Kaoru and Tomita, Hiroyuki and Kidoya, Hiroyasu and Shiraki, Yukihiro and Enomoto, Atsushi and Kajiyama, Hiroaki}},
  issn         = {{2045-2322}},
  keywords     = {{Neutrophil; Ovarian carcinoma; Peritoneal metastasis; Prognosis}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer}},
  url          = {{http://dx.doi.org/10.1038/s41598-025-05010-3}},
  doi          = {{10.1038/s41598-025-05010-3}},
  volume       = {{15}},
  year         = {{2025}},
}