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Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)

Pollesello, Piero ; Ovaska, Martti ; Tenhunen, J. ; Vidgren, J. ; Yliperttula, Marjo ; Tilgmann, Carola LU orcid ; Lotta, T. and Kaivola, Juha (2004) US 6774103 B1
Abstract
This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban
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inventor
Pollesello, Piero ; Ovaska, Martti ; Tenhunen, J. ; Vidgren, J. ; Yliperttula, Marjo ; LU orcid ; Lotta, T. and Kaivola, Juha
publishing date
type
Patent
publication status
published
subject
keywords
calcium-ATPase, phospholamban, drug discovery
patent number
US 6774103 B1
language
English
LU publication?
no
id
63d51c6e-a488-48a7-8758-a5e1b8640f1a
date added to LUP
2016-04-20 13:24:52
date last changed
2019-03-08 02:21:46
@misc{63d51c6e-a488-48a7-8758-a5e1b8640f1a,
  abstract     = {{This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms. The invention also relates to phospholamban inhibiting compounds with certain structural, physicochemical and spatial characteristics that allow for the interaction of said compounds with specific residues of the active site of phospholamban}},
  author       = {{Pollesello, Piero and Ovaska, Martti and Tenhunen, J. and Vidgren, J. and Yliperttula, Marjo and Tilgmann, Carola and Lotta, T. and Kaivola, Juha}},
  keywords     = {{calcium-ATPase; phospholamban; drug discovery}},
  language     = {{eng}},
  month        = {{08}},
  note         = {{Patent, Patent Number: US 6774103 B1}},
  title        = {{Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors)}},
  year         = {{2004}},
}