pH Sensitive Tubules of a Bile Acid Derivative: a Tubule Opening by Release of Wall Leaves
di Gregorio, Maria Chiara ; Pavel, Nicolae V. ; Jover, Aida ; Meijide, Francisco ; Tato, José Vázquez ; Soto Tellini, Victor H. ; Vargas, Ariel Alfaro ; Regev, Oren ; Kasavi, Yaron and Schillén, Karin LU
, et al.
(2013)
In Physical Chemistry Chemical Physics
15(20).
p.7560-7566
- Abstract
- Tubules formed by self-assembly of organic molecules have a vast potential in nanotechnology
applications and the introduction of sensitivity to stimuli into self-assembly tubules represents a
particularly attractive feature. Here we report on the preparation and characterization of a
molecule obtained by chemical modification of a natural bile acid, a biological surfactant, that
self-assembles in pH sensitive tubules in aqueous solutions.
The tubules, that are rigid, single-walled and with a diameter of 60 nm, form at pH 8-9 and open
up when the pH is increased. The transition is reversible, it occurs in the pH range of 9-10 with
an opening mechanism that is remarkably... (More) - Tubules formed by self-assembly of organic molecules have a vast potential in nanotechnology
applications and the introduction of sensitivity to stimuli into self-assembly tubules represents a
particularly attractive feature. Here we report on the preparation and characterization of a
molecule obtained by chemical modification of a natural bile acid, a biological surfactant, that
self-assembles in pH sensitive tubules in aqueous solutions.
The tubules, that are rigid, single-walled and with a diameter of 60 nm, form at pH 8-9 and open
up when the pH is increased. The transition is reversible, it occurs in the pH range of 9-10 with
an opening mechanism that is remarkably different from those so far proposed in the literature. It
involves a release of wall layers similar to leaves, and is determined by a drastic pH-triggered
change in the molecular arrangement, which in turn induces a radical modification of the wall
curvature. The description of the morphological transformation is performed by means of
cryogenic transmission electron microscopy and represent, to our knowledge, the first detailed
visualization of pH stimulated tubule opening. UV and circular dichroism spectroscopies are
used to investigate the evolution at the molecular level. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3629707
- author
- di Gregorio, Maria Chiara
; Pavel, Nicolae V.
; Jover, Aida
; Meijide, Francisco
; Tato, José Vázquez
; Soto Tellini, Victor H.
; Vargas, Ariel Alfaro
; Regev, Oren
; Kasavi, Yaron
and Schillén, Karin
LU
, et al. (More)
- di Gregorio, Maria Chiara
; Pavel, Nicolae V.
; Jover, Aida
; Meijide, Francisco
; Tato, José Vázquez
; Soto Tellini, Victor H.
; Vargas, Ariel Alfaro
; Regev, Oren
; Kasavi, Yaron
; Schillén, Karin
LU
and Galantini, Luciano
(Less)
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Chemistry Chemical Physics
- volume
- 15
- issue
- 20
- pages
- 7560 - 7566
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000318306100018
- scopus:84877246199
- ISSN
- 1463-9084
- DOI
- 10.1039/C3CP00121K
- language
- English
- LU publication?
- yes
- id
- 63e1371c-0eb7-4414-ba55-470bf1e6393a (old id 3629707)
- date added to LUP
- 2016-04-01 10:38:32
- date last changed
- 2022-04-20 03:57:47
@article{63e1371c-0eb7-4414-ba55-470bf1e6393a,
abstract = {{Tubules formed by self-assembly of organic molecules have a vast potential in nanotechnology<br/><br>
applications and the introduction of sensitivity to stimuli into self-assembly tubules represents a<br/><br>
particularly attractive feature. Here we report on the preparation and characterization of a<br/><br>
molecule obtained by chemical modification of a natural bile acid, a biological surfactant, that<br/><br>
self-assembles in pH sensitive tubules in aqueous solutions.<br/><br>
The tubules, that are rigid, single-walled and with a diameter of 60 nm, form at pH 8-9 and open<br/><br>
up when the pH is increased. The transition is reversible, it occurs in the pH range of 9-10 with<br/><br>
an opening mechanism that is remarkably different from those so far proposed in the literature. It<br/><br>
involves a release of wall layers similar to leaves, and is determined by a drastic pH-triggered<br/><br>
change in the molecular arrangement, which in turn induces a radical modification of the wall<br/><br>
curvature. The description of the morphological transformation is performed by means of<br/><br>
cryogenic transmission electron microscopy and represent, to our knowledge, the first detailed<br/><br>
visualization of pH stimulated tubule opening. UV and circular dichroism spectroscopies are<br/><br>
used to investigate the evolution at the molecular level.}},
author = {{di Gregorio, Maria Chiara and Pavel, Nicolae V. and Jover, Aida and Meijide, Francisco and Tato, José Vázquez and Soto Tellini, Victor H. and Vargas, Ariel Alfaro and Regev, Oren and Kasavi, Yaron and Schillén, Karin and Galantini, Luciano}},
issn = {{1463-9084}},
language = {{eng}},
number = {{20}},
pages = {{7560--7566}},
publisher = {{Royal Society of Chemistry}},
series = {{Physical Chemistry Chemical Physics}},
title = {{pH Sensitive Tubules of a Bile Acid Derivative: a Tubule Opening by Release of Wall Leaves}},
url = {{http://dx.doi.org/10.1039/C3CP00121K}},
doi = {{10.1039/C3CP00121K}},
volume = {{15}},
year = {{2013}},
}