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Malignant hyperthermia, a Scandinavian update.

Broman, Marcus Ewert LU ; Islander, Gunilla LU and Müller, C R (2015) In Acta Anaesthesiologica Scandinavica 59(8). p.951-961
Abstract
Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Anaesthesiologica Scandinavica
volume
59
issue
8
pages
951 - 961
publisher
Wiley-Blackwell
external identifiers
  • pmid:25989378
  • wos:000359421100001
  • scopus:84938749461
  • pmid:25989378
ISSN
0001-5172
DOI
10.1111/aas.12541
language
English
LU publication?
yes
id
641e011f-ae69-4bf8-9e49-0d46950e1b72 (old id 5448644)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25989378?dopt=Abstract
date added to LUP
2016-04-01 09:51:18
date last changed
2022-04-11 23:34:04
@article{641e011f-ae69-4bf8-9e49-0d46950e1b72,
  abstract     = {{Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.}},
  author       = {{Broman, Marcus Ewert and Islander, Gunilla and Müller, C R}},
  issn         = {{0001-5172}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{951--961}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Anaesthesiologica Scandinavica}},
  title        = {{Malignant hyperthermia, a Scandinavian update.}},
  url          = {{http://dx.doi.org/10.1111/aas.12541}},
  doi          = {{10.1111/aas.12541}},
  volume       = {{59}},
  year         = {{2015}},
}