Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Metylprednisolon alltmer ifrågasatt vid behandling av akut ryggmärgsskada

Kronvall, Erik LU ; Sayer, Faisal T LU and Nilsson, Ola G LU (2005) In Läkartidningen 102(24-25). p.1887-1890
Abstract

Methylprednisolone (MP) has, through the results from the clinical multi-center studies National Acute Spinal Cord Injury Study II and III, during the 1990's become standard treatment in acute spinal cord injury (ASCI). Critical reappraisals of the data have later shown that analyses have been made on subgroups of the study-populations and argue that the results are based on statistical artefacts. This, combined with the failure to show improved functional recovery, puts into question earlier conclusions drawn on the efficacy of MP on ASCI. This review of the recent literature on the subject concludes that there is no scientific evidence to support MP as standard treatment in ASCI.

Please use this url to cite or link to this publication:
author
; and
alternative title
Methylprednisolone in the treatment of acute spinal cord injury has become more and more questioned
publishing date
type
Contribution to specialist publication or newspaper
publication status
published
subject
keywords
Acute Disease, Humans, Methylprednisolone/administration & dosage, Multicenter Studies as Topic, Neurologic Examination, Neuroprotective Agents/administration & dosage, Randomized Controlled Trials as Topic, Recovery of Function, Spinal Cord Injuries/drug therapy
in
Läkartidningen
volume
102
issue
24-25
pages
1887 - 1890
publisher
Swedish Medical Association
external identifiers
  • pmid:16044768
ISSN
0023-7205
language
Swedish
LU publication?
no
id
643185db-e704-4c65-af3a-82c1684ba72d
alternative location
http://www.lakartidningen.se/OldPdfFiles/2005/30335.pdf
date added to LUP
2019-06-25 09:46:40
date last changed
2021-09-23 04:04:47
@misc{643185db-e704-4c65-af3a-82c1684ba72d,
  abstract     = {{<p>Methylprednisolone (MP) has, through the results from the clinical multi-center studies National Acute Spinal Cord Injury Study II and III, during the 1990's become standard treatment in acute spinal cord injury (ASCI). Critical reappraisals of the data have later shown that analyses have been made on subgroups of the study-populations and argue that the results are based on statistical artefacts. This, combined with the failure to show improved functional recovery, puts into question earlier conclusions drawn on the efficacy of MP on ASCI. This review of the recent literature on the subject concludes that there is no scientific evidence to support MP as standard treatment in ASCI.</p>}},
  author       = {{Kronvall, Erik and Sayer, Faisal T and Nilsson, Ola G}},
  issn         = {{0023-7205}},
  keywords     = {{Acute Disease; Humans; Methylprednisolone/administration & dosage; Multicenter Studies as Topic; Neurologic Examination; Neuroprotective Agents/administration & dosage; Randomized Controlled Trials as Topic; Recovery of Function; Spinal Cord Injuries/drug therapy}},
  language     = {{swe}},
  month        = {{07}},
  number       = {{24-25}},
  pages        = {{1887--1890}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Läkartidningen}},
  title        = {{Metylprednisolon alltmer ifrågasatt vid behandling av akut ryggmärgsskada}},
  url          = {{http://www.lakartidningen.se/OldPdfFiles/2005/30335.pdf}},
  volume       = {{102}},
  year         = {{2005}},
}