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Systematic review of the healthcare cost of bronchopulmonary dysplasia

Humayun, Jhangir ; Löfqvist, Chatarina ; Ley, David LU ; Hellström, Ann and Gyllensten, Hanna (2021) In BMJ Open 11(8).
Abstract

To determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight. Systematic literature review. PubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further searched to identify eligible references and citations. Two independent reviewers extracted data with a prespecified data extraction sheet, including items from a published checklist for quality assessment. The costs in the included studies are reported descriptively. Costs of BPD. The 13 included studies reported the total costs or marginal... (More)

To determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight. Systematic literature review. PubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further searched to identify eligible references and citations. Two independent reviewers extracted data with a prespecified data extraction sheet, including items from a published checklist for quality assessment. The costs in the included studies are reported descriptively. Costs of BPD. The 13 included studies reported the total costs or marginal costs of BPD. Most studies reported costs during birth hospitalisation (cost range: Int$21 392–Int$1 094 509 per child, equivalent to €19 103–€977 397, in 2019) and/or during the first year of life. One study reported costs during the first 2 years; two other studies reported costs later, during the preschool period and one study included a long-term follow-up. The highest mean costs were associated with infants born at extremely low gestational ages. The quality assessment indicated a low risk of bias in the reported findings of included studies. This study was the first systematic review of costs associated with BPD. We confirmed previous reports of high costs and described the long-term follow-up necessary for preterm infants with BPD, particularly infants of very low gestational age. Moreover, we identified a need for studies that estimate costs outside hospitals and after the first year of life. CRD42020173234.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic airways disease, health economics, paediatric thoracic medicine, paediatrics, respiratory medicine (see thoracic medicine)
in
BMJ Open
volume
11
issue
8
article number
e045729
publisher
BMJ Publishing Group
external identifiers
  • scopus:85112748671
  • pmid:34376441
ISSN
2044-6055
DOI
10.1136/bmjopen-2020-045729
language
English
LU publication?
yes
id
64387e3d-7a4d-43ac-9130-c19eb175c63d
date added to LUP
2021-09-14 13:05:02
date last changed
2024-03-08 17:26:39
@article{64387e3d-7a4d-43ac-9130-c19eb175c63d,
  abstract     = {{<p>To determine the costs directly or indirectly related to bronchopulmonary dysplasia (BPD) in preterm infants. The secondary objective was to stratify the costs based on gestational age and/or birth weight. Systematic literature review. PubMed and Scopus were searched on 3 February 2020. Studies were selected based on eligibility criteria by two independent reviewers. Included studies were further searched to identify eligible references and citations. Two independent reviewers extracted data with a prespecified data extraction sheet, including items from a published checklist for quality assessment. The costs in the included studies are reported descriptively. Costs of BPD. The 13 included studies reported the total costs or marginal costs of BPD. Most studies reported costs during birth hospitalisation (cost range: Int$21 392–Int$1 094 509 per child, equivalent to €19 103–€977 397, in 2019) and/or during the first year of life. One study reported costs during the first 2 years; two other studies reported costs later, during the preschool period and one study included a long-term follow-up. The highest mean costs were associated with infants born at extremely low gestational ages. The quality assessment indicated a low risk of bias in the reported findings of included studies. This study was the first systematic review of costs associated with BPD. We confirmed previous reports of high costs and described the long-term follow-up necessary for preterm infants with BPD, particularly infants of very low gestational age. Moreover, we identified a need for studies that estimate costs outside hospitals and after the first year of life. CRD42020173234.</p>}},
  author       = {{Humayun, Jhangir and Löfqvist, Chatarina and Ley, David and Hellström, Ann and Gyllensten, Hanna}},
  issn         = {{2044-6055}},
  keywords     = {{chronic airways disease; health economics; paediatric thoracic medicine; paediatrics; respiratory medicine (see thoracic medicine)}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Systematic review of the healthcare cost of bronchopulmonary dysplasia}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2020-045729}},
  doi          = {{10.1136/bmjopen-2020-045729}},
  volume       = {{11}},
  year         = {{2021}},
}