Sensitization to palladium in Europe
(2015) In Contact Dermatitis 72(1). p.11-19- Abstract
- BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were... (More)
- BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were tested. Relative to 3% Na2PdCl4, 4% Na2PdCl4 did not add any information. Two per cent Na2PdCl4 resulted in more doubtful reactions and showed suboptimal reactivity. The prevalence of palladium sensitization doubled with Na2PdCl4 and was similar to that of nickel. Interestingly, in contrast to nickel sensitization, palladium sensitization was not related to female sex. ConclusionsThree per cent Na2PdCl4 pet. is the most suitable patch test concentration. Sensitization to palladium is almost as prevalent as sensitization to nickel. The sex distribution is different between nickel-sensitized and palladium-sensitized patients, suggesting different sources of exposure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4941570
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, cross-reactivity, epidemiology, metals, nickel, oral disease, palladium
- in
- Contact Dermatitis
- volume
- 72
- issue
- 1
- pages
- 11 - 19
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000346594700003
- scopus:84919363698
- pmid:25348727
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12295
- language
- English
- LU publication?
- yes
- id
- 64404219-58e9-46ec-9494-bc5758054d61 (old id 4941570)
- date added to LUP
- 2016-04-01 10:52:44
- date last changed
- 2022-05-06 02:22:47
@article{64404219-58e9-46ec-9494-bc5758054d61, abstract = {{BackgroundRecently, sodium tetrachloropalladate (Na2PdCl4) was found to be a more sensitive palladium patch test allergen than palladium dichloride (PdCl2). ObjectivesTo determine the optimal test concentration of Na2PdCl4, to evaluate the prevalence of palladium sensitization with Na2PdCl4 and PdCl2, and to compare the results with nickel sensitization in a European multicentre study. Materials and methodsIn addition to the European or national baseline series including NiSO(4)6H(2)0 5% pet., consecutive patients were tested with PdCl2 and Na2PdCl4 2%, 3% and 4% pet. in eight European dermatology clinics. The age and sex distributions were also evaluated in patients sensitized to nickel and palladium. ResultsIn total, 1651 patients were tested. Relative to 3% Na2PdCl4, 4% Na2PdCl4 did not add any information. Two per cent Na2PdCl4 resulted in more doubtful reactions and showed suboptimal reactivity. The prevalence of palladium sensitization doubled with Na2PdCl4 and was similar to that of nickel. Interestingly, in contrast to nickel sensitization, palladium sensitization was not related to female sex. ConclusionsThree per cent Na2PdCl4 pet. is the most suitable patch test concentration. Sensitization to palladium is almost as prevalent as sensitization to nickel. The sex distribution is different between nickel-sensitized and palladium-sensitized patients, suggesting different sources of exposure.}}, author = {{Muris, Joris and Goossens, An and Goncalo, Margarida and Bircher, Andreas J. and Gimenez-Arnau, Ana and Foti, Caterina and Bruze, Magnus and Andersen, Klaus Ejner and Rustemeyer, Thomas and Feilzer, Albert J. and Kleverlaan, Cornelis J.}}, issn = {{0105-1873}}, keywords = {{allergic contact dermatitis; cross-reactivity; epidemiology; metals; nickel; oral disease; palladium}}, language = {{eng}}, number = {{1}}, pages = {{11--19}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Sensitization to palladium in Europe}}, url = {{http://dx.doi.org/10.1111/cod.12295}}, doi = {{10.1111/cod.12295}}, volume = {{72}}, year = {{2015}}, }